Altered synaptic structure and function is a major hallmark of fragile X syndrome (FXS),
autism spectrum disorders (ASDs), and other intellectual disabilities (IDs), which are�…

Chloride homeostasis, the main determinant factor for the dynamic tuning of GABAergic
inhibition during development, has emerged as a key element altered in a wide variety of�…

Abstract Fragile X Syndrome (FXS) is a monogenetic form of intellectual disability and
autism in which well-established knockout (KO) animal models point to neuronal�…

Normal brain development is highly dependent on the timely coordinated actions of genetic
and environmental processes, and an aberration can lead to neurodevelopmental disorders�…

The hippocampus (HPC) and medial prefrontal cortex (mPFC) have well-established roles in
cognition, emotion, and sensory processing. In recent years, interests have shifted towards�…

Fragile X syndrome (FXS) is a genetic neurodevelopmental disorder characterized by
intellectual disability and is related to autism. FXS is caused by mutations of the fragile X�…

Intellectual disability (ID) and autism spectrum disorder (ASD) are neurodevelopmental
disorders that have become a primary clinical and social concern, with a prevalence of 2�…

Astrocytes have an important role in neuronal maturation and synapse function in the brain.
The interplay between astrocytes and neurons is found to be altered in many�…

In neuronal precursors and immature neurons, the depolarizing (excitatory) effect of γ-
Aminobutyric acid (GABA) signaling is associated with elevated [Cl−] i; as brain cells mature�…

Benzodiazepines (BZDs) are a class of widely prescribed psychotropic drugs that modulate
activity of GABAA receptors (GABAARs), neurotransmitter-gated ion channels critical for�…