N-myc down-regulated gene 1 (NDRG1) is a known metastasis suppressor in multiple
cancers, being also involved in embryogenesis and development, cell growth and�…

Breed Predispositions to Disease in Dogs and Cats, Third Edition provides a comprehensive
exploration of current knowledge of breed predispositions based on rigorous examination of�…

In hereditary neuropathies, next-generation sequencing techniques are producing a vast
number of candidate gene mutations that need to be verified or excluded by careful�…

Purpose: Copy-number variations as a mutational mechanism contribute significantly to
human disease. Approximately one-half of the patients with Charcot–Marie–Tooth (CMT)�…

Congenital hypomyelinating polyneuropathy (HPN) restricted to the peripheral nervous
system was reported in 1989 in two Golden Retriever (GR) littermates. Recently, four�…

Simple Summary This review explores various inherited neurological conditions found in
dogs, which can be present from birth or develop later in life. Researchers use two main�…

N-myc downstream-regulated gene 1 (NDRG1) is induced by cellular stress such as hypoxia
and DNA damage, and in humans, germ line mutations cause Charcot-Marie-Tooth disease�…

An inherited polyneuropathy (PN) observed in Leonberger dogs has clinical similarities to a
genetically heterogeneous group of peripheral neuropathies termed Charcot-Marie-Tooth�…

N‐myc downstream‐regulated gene 1 (NDRG1) is a tumour suppressor involved in
vesicular trafficking and stress response. NDRG1 participates in peripheral nerve�…

Background Many inherited polyneuropathies (PN) observed in dogs have clinical
similarities to the genetically heterogeneous group of Charcot-Marie-Tooth (CMT) peripheral�…