Biological roles of adenine methylation in RNA

K Boulias, EL Greer�- Nature Reviews Genetics, 2023 - nature.com
Abstract N 6-Methyladenosine (m6A) is one of the most abundant modifications of the
epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in�…

[HTML][HTML] The proteins of mRNA modification: writers, readers, and erasers

MN Flamand, M Tegowski…�- Annual review of�…, 2023 - annualreviews.org
Over the past decade, mRNA modifications have emerged as important regulators of gene
expression control in cells. Fueled in large part by the development of tools for detecting�…

[HTML][HTML] N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer's disease

AM Shafik, F Zhang, Z Guo, Q Dai, K Pajdzik, Y Li…�- Genome biology, 2021 - Springer
Abstract Background N6-methyladenosine (m 6 A) modification is known to impact many
aspects of RNA metabolism, including mRNA stability and translation, and is highly�…

[HTML][HTML] The role of m6A modification in physiology and disease

C Yang, Y Hu, B Zhou, Y Bao, Z Li, C Gong…�- Cell death &�…, 2020 - nature.com
Similar to DNA epigenetic modifications, multiple reversible chemical modifications on RNAs
have been uncovered in a new layer of epigenetic modification. N6-methyladenosine (m6A)�…

[HTML][HTML] Oncofetal protein IGF2BPs in human cancer: functions, mechanisms and therapeutic potential

TY Zhu, LL Hong, ZQ Ling�- Biomarker research, 2023 - Springer
Abstract N6-methyladenosine (m6A) is the most prevalent and well-characterized internal
chemical modification in eukaryotic RNA, influencing gene expression and phenotypic�…

METTL3 from target validation to the first small-molecule inhibitors: a medicinal chemistry journey

F Fiorentino, M Menna, D Rotili…�- Journal of Medicinal�…, 2023 - ACS Publications
RNA methylation is a critical mechanism for regulating the transcription and translation of
specific sequences or for eliminating unnecessary sequences during RNA maturation�…

Ythdf is a N6‐methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila

L Worpenberg, C Paolantoni, S Longhi…�- The EMBO�…, 2021 - embopress.org
Abstract N6‐methyladenosine (m6A) regulates a variety of physiological processes through
modulation of RNA metabolism. This modification is particularly enriched in the nervous�…

IFN regulatory Factor-1 induced macrophage pyroptosis by modulating m6A modification of circ_0029589 in patients with acute coronary syndrome

M Guo, R Yan, Q Ji, H Yao, M Sun, L Duan…�- International�…, 2020 - Elsevier
Background Pyroptosis is identified as a novel form of inflammatory programmed cell death
and has been recently found to be closely related to atherosclerosis (AS). We found that IFN�…

[HTML][HTML] m6A methylation in cardiovascular diseases: from mechanisms to therapeutic potential

L Li, N Xu, J Liu, Z Chen, X Liu, J Wang�- Frontiers in genetics, 2022 - frontiersin.org
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide.
Recent studies have shown that n6-methyladenosine (m6A) plays a major role in�…

[HTML][HTML] The role of M6A modification in the regulation of tumor-related lncRNAs

Y Lan, B Liu, H Guo�- Molecular Therapy-Nucleic Acids, 2021 - cell.com
N 6-methyladenosine (m 6 A) is the most abundant modification in eukaryotic cells, and it
regulates RNA transcription, processing, splicing, degradation, and translation. Long non�…