Sensory areas are spontaneously active in the absence of sensory stimuli. This
spontaneous activity has long been studied; however, its functional role remains largely�…

The field of network neuroscience has emerged as a natural framework for the study of the
brain and has been increasingly applied across divergent problems in neuroscience. From a�…

Abstract Models of cognitive function typically focus on the cerebral cortex and hence
overlook functional links to subcortical structures. This view does not consider the role of the�…

The intrinsic functional organization of the brain changes into older adulthood. Age
differences are observed at multiple spatial scales, from global reductions in modularity and�…

The necessity of the human hippocampus for remote autobiographical recall remains
fiercely debated. The standard model of consolidation predicts a time-limited role for the�…

The complexity of the human brain gives the illusion that brain activity is intrinsically high-
dimensional. Nonlinear dimensionality-reduction methods such as uniform manifold�…

Prior studies of aging and Alzheimer disease have evaluated resting state functional
connectivity (FC) using either seed-based correlation (SBC) or independent component�…

Background Alzheimer's disease (AD) is a neurodegenerative disease associated with
widespread disruptions in intrinsic local specialization and global integration in the�…

Most human neuroscience research to date has focused on statistical approaches that
describe stationary patterns of localized neural activity or blood flow. While these patterns�…

Human cognition is dynamic, alternating over time between externally-focused states and
more abstract, often self-generated, patterns of thought. Although cognitive neuroscience�…