This report calls on the nation—its leaders, its mental health research and service provision
agencies, its schools, its primary care medical systems, its community-based organizations�…

The hippocampus serves a critical role in declarative memory—our capacity to recall
everyday facts and events. Recent studies using functional brain imaging in humans and�…

The aging of the central nervous system and the development of incapacitating neurological
diseases like Alzheimer's disease (AD) are generally associated with a wide range of�…

A theory of multiple parallel memory systems in the brain of the rat is described. Each system
consists of a series of interconnected neural structures. The “central structures” of the three�…

The hippocampus receives its major cortical input from the medial entorhinal cortex (MEC)
and the lateral entorhinal cortex (LEC). It is commonly believed that the MEC provides�…

Episodic memories are encoded by a sparse population of hippocampal neurons. In mice,
optogenetic manipulation of this memory engram established that these neurons are�…

Some theories of memory propose that the hippocampus integrates the individual items and
events of experience within a contextual or spatial framework. The hippocampus receives�…

Matrix metalloproteinases (MMPs) are extracellular proteases that have well recognized
roles in cell signaling and remodeling in many tissues. In the brain, their activation and�…

Neuropathic pain is a chronic pain that results from lesion or dysfunction of the nervous
system. Depression and cognitive decline are often coupled to chronic pain, suggesting the�…

Oxytocin is an essential hormone for mammalian labor and lactation. Here, we show a new
function of oxytocin in causing plastic changes in hippocampal synapses during�…