The mechanisms involved in plasticity in the nervous system are thought to support
cognition, and some of these processes are affected during normal ageing. Notably�…

Aging is associated with specific impairments of learning and memory, some of which are
similar to those caused by hippocampal damage. Studies of the effects of aging on�…

There is widespread evidence that memory deteriorates with aging, however the exact
mechanisms that underlie these changes are not well understood. Given the growing size of�…

Converging data from rodents and humans have demonstrated an age-related decline in
pattern separation abilities (the ability to discriminate among similar experiences). Several�…

Spatial navigation is a complex cognitive skill that is necessary for everyday functioning in
the environment. However, navigational skills are not typically measured in most test�…

The use of virtual environment (VE) technology to assess spatial navigation in humans has
become increasingly common and provides an opportunity to quantify age-related deficits in�…

Normal aging is often accompanied by impairments in forming new memories, and studies
of aging rodents have revealed structural and functional changes to the hippocampus that�…

In order to cope with normal cognitive aging we must understand the patterns and
neurofunctional underpinnings of cognitive and behavioral changes throughout adulthood�…

Age differences in navigation strategies have been demonstrated in animals, with aged
animals more likely to prefer an egocentric (route) strategy and younger animals more likely�…

Background A dearth of laboratory tests to study actual human approach-avoidance
behavior has complicated translational research on anxiety. The elevated plus-maze (EPM)�…