Striosomes form neurochemically specialized compartments of the striatum embedded in a
large matrix made up of modules called matrisomes. Striosome-matrix architecture is�…

The striatum is a heterogeneous structure with a diverse range of neuron types and
neuromodulators. Three decades of anatomical and biochemical studies have established�…

Neurophotonics was launched in 2014 coinciding with the launch of the BRAIN Initiative
focused on development of technologies for advancement of neuroscience. For the last�…

The striosome compartment within the dorsal striatum has been implicated in reinforcement
learning and regulation of motivation, but how striosomal neurons contribute to these�…

The dopamine systems of the brain powerfully influence movement and motivation. We
demonstrate that striatonigral fibers originating in striosomes form highly unusual bouquet�…

One of the biggest unsolved questions in neuroscience is how molecules and neuronal
circuitry create behaviors, and how their misregulation or dysfunction results in neurological�…

The circuitry of the striatum is characterized by two organizational plans: the division into
striosome and matrix compartments, thought to mediate evaluation and action, and the direct�…

Striosomes were discovered several decades ago as neurochemically identified zones in
the striatum, yet technical hurdles have hampered the study of the functions of these striatal�…

Presynaptic cannabinoid-1 receptors (CB1-R) bind endogenous and exogenous
cannabinoids to modulate neurotransmitter release. CB1-Rs are expressed throughout the�…

Food intake, which is a highly reinforcing behavior, provides nutrients required for survival in
all animals. However, when fat and sugar consumption goes beyond the daily needs, it can�…