Diabetic sensorimotor peripheral neuropathy (DSPN) is a serious complication of diabetes
mellitus and is associated with increased mortality, lower-limb amputations and distressing�…

Diabetic peripheral neuropathy (DPN) affects up to 50% of patients with diabetes and is a
major cause of morbidity and increased mortality. Its clinical manifestations include painful�…

Diabetic neuropathy is a common complication of both type 1 and type 2 diabetes, which
affects over 90% of the diabetic patients. Although pain is one of the main symptoms of�…

The pain matrix is conceptualised here as a fluid system composed of several interacting
networks. A nociceptive matrix receiving spinothalamic projections (mainly posterior�…

Painful diabetic peripheral neuropathy (DPN) is common, is associated with significant
reduction in quality of life and poses major treatment challenges to the practising physician�…

Although a number of the diabetic neuropathies may result in painful symptomatology, this
review focuses on the most common: chronic sensorimotor distal symmetrical�…

Diabetic peripheral neuropathy (DPN) is a common chronic complication of diabetes
mellitus. It leads to distressing and expensive clinical sequelae such as foot ulceration, leg�…

Abstract Purpose of Review The prevalence of diabetes mellitus and its chronic
complications are increasing to epidemic proportions. This will unfortunately result in�…

Neuropathy will afflict over half of the estimated 460 million people worldwide who have
diabetes, 303 of whom approximately onethird will also develop neuropathic pain. 2 The�…

The prevalence of diabetes mellitus and its chronic complications continue to increase
alarmingly. Consequently, the massive expenditure on diabetic distal symmetrical�…