[HTML][HTML] Treatment of overdose in the synthetic opioid era

P Skolnick�- Pharmacology & therapeutics, 2022 - Elsevier
Overdose deaths are often viewed as the leading edge of the opioid epidemic which has
gripped the United States over the past two decades (Skolnick, 2018a). This emphasis is�…

[HTML][HTML] Estimating naloxone need in the USA across fentanyl, heroin, and prescription opioid epidemics: a modelling study

MA Irvine, D Oller, J Boggis, B Bishop…�- The Lancet Public�…, 2022 - thelancet.com
Background The US overdose crisis is driven by fentanyl, heroin, and prescription opioids.
One evidence-based policy response has been to broaden naloxone distribution, but how�…

Trends in drug overdose deaths among US adolescents, January 2010 to June 2021

J Friedman, M Godvin, CL Shover, JP Gone, H Hansen…�- Jama, 2022 - jamanetwork.com
Methods| We calculated drug overdose deaths per 100 000 population for adolescents
(aged 14-18 years), compared with the overall population, from January 2010 to June 2021�…

Implementation of safe supply alternatives during intersecting COVID-19 and overdose health emergencies in British Columbia, Canada, 2021

R McNeil, T Fleming, S Mayer…�- …�journal of public�…, 2022 - ajph.aphapublications.org
Objectives. To explore the implementation and effectiveness of the British Columbia,
Canada, risk mitigation guidelines among people who use drugs, focusing on how�…

Spatiotemporal analysis exploring the effect of law enforcement drug market disruptions on overdose, Indianapolis, Indiana, 2020–2021

B Ray, SJ Korzeniewski, G Mohler…�- …�journal of public�…, 2023 - ajph.aphapublications.org
Objectives. To test the hypothesis that law enforcement efforts to disrupt local drug markets
by seizing opioids or stimulants are associated with increased spatiotemporal clustering of�…

Charting the fourth wave: Geographic, temporal, race/ethnicity and demographic trends in polysubstance fentanyl overdose deaths in the United States, 2010–2021

J Friedman, CL Shover�- Addiction, 2023 - Wiley Online Library
Aims To characterize polysubstance death in the United States during the transition to the
fourth wave of the drug overdose crisis. To characterize co‐involved substances in fatal�…

Buprenorphine versus methadone for the treatment of opioid dependence: a systematic review and meta-analysis of randomised and observational studies

L Degenhardt, B Clark, G Macpherson…�- The Lancet�…, 2023 - thelancet.com
Background Opioid dependence is associated with substantial health and social burdens,
and opioid agonist treatment (OAT) is highly effective in improving multiple outcomes for�…

Association of methamphetamine and opioid use with nonfatal overdose in rural communities

PT Korthuis, RR Cook, CA Foot, G Leichtling…�- JAMA network�…, 2022 - jamanetwork.com
Importance Overdoses continue to increase in the US, but the contribution of
methamphetamine use is understudied in rural communities. Objective To estimate the�…

[HTML][HTML] Overdose mortality rates for opioids and stimulant drugs are substantially higher in men than in women: state-level analysis

ER Butelman, Y Huang, DH Epstein…�- …, 2023 - nature.com
Drug overdoses from opioids and stimulants are a major cause of mortality in the United
States. It is unclear if there are stable sex differences in overdose mortality for these drugs�…

Reducing opioid use disorder and overdose deaths in the United States: a dynamic modeling analysis

EJ Stringfellow, TY Lim, K Humphreys…�- Science�…, 2022 - science.org
Opioid overdose deaths remain a major public health crisis. We used a system dynamics
simulation model of the US opioid-using population age 12 and older to explore the impacts�…