Ageing and age-related diseases share some basic mechanistic pillars that largely
converge on inflammation. During ageing, chronic, sterile, low-grade inflammation—called�…

Evidence for a close bidirectional link between the brain and the gut has led to a paradigm
shift in neurology, especially in the case of Parkinson disease (PD), in which gastrointestinal�…

Longer human lives have led to a global burden of late-life disease. However, some older
people experience little ill health, a trait that should be extended to the general population�…

Most patients diagnosed with resected pancreatic adenocarcinoma (PDAC) survive less
than 5 years, but a minor subset survives longer. Here, we dissect the role of the tumor�…

Outer membrane vesicles (OMVs) play vital roles in bacterial communication both
intraspecifically and interspecifically. However, extracellular mechanisms of gut microbiota�…

Osteoarthritis is a highly prevalent disease particularly in subjects over 65 years of age
worldwide. While in the past it was considered a mere consequence of cartilage degradation�…

Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disorder, in which the
clinical manifestations may be influenced by genetic and unknown environmental factors�…

Our understanding of the human gut microbiome continues to evolve at a rapid pace, but
practical application of thisknowledge is still in its infancy. This review discusses the type of�…

How bacterial chemotaxis is performed is much better understood than why. Traditionally,
chemotaxis has been understood as a foraging strategy by which bacteria enhance their�…

Host–microbiota interactions are fundamental for the development of the immune system.
Drastic changes in modern environments and lifestyles have led to an imbalance of this�…