The discovery of the default mode network (DMN) has revolutionized our understanding of
the workings of the human brain. Here, I review developments that led to the discovery of the�…

The default mode network (DMN) is classically considered an 'intrinsic'system, specializing
in internally oriented cognitive processes such as daydreaming, reminiscing and future�…

The brain's default mode network consists of discrete, bilateral and symmetrical cortical
areas, in the medial and lateral parietal, medial prefrontal, and medial and lateral temporal�…

Importance Major depressive disorder (MDD) has been linked to imbalanced
communication among large-scale brain networks, as reflected by abnormal resting-state�…

Human functional MRI (fMRI) research primarily focuses on analyzing data averaged across
groups, which limits the detail, specificity, and clinical utility of fMRI resting-state functional�…

Cultivation of mindfulness, the nonjudgmental awareness of experiences in the present
moment, produces beneficial effects on well-being and ameliorates psychiatric and stress�…

The insula is a brain structure implicated in disparate cognitive, affective, and regulatory
functions, including interoceptive awareness, emotional responses, and empathic�…

The posterior cingulate cortex is a highly connected and metabolically active brain region.
Recent studies suggest it has an important cognitive role, although there is no consensus�…

Effective motor performance is important for surviving and thriving, and skilled movement is
critical in many activities. Much theorizing over the past few decades has focused on how�…

Thirty years of brain imaging research has converged to define the brain's default network—
a novel and only recently appreciated brain system that participates in internal modes of�…