Updating the striatal–pallidal wiring diagram
The striatal and pallidal complexes are basal ganglia structures that orchestrate learning
and execution of flexible behavior. Models of how the basal ganglia subserve these�…
and execution of flexible behavior. Models of how the basal ganglia subserve these�…
Compensatory mechanisms in Parkinson's disease: circuits adaptations and role in disease modification
The motor features of Parkinson's disease (PD) are well known to manifest only when striatal
dopaminergic deficit reaches 60–70%. Thus, PD has a long pre-symptomatic and pre-motor�…
dopaminergic deficit reaches 60–70%. Thus, PD has a long pre-symptomatic and pre-motor�…
Targeting thalamic circuits rescues motor and mood deficits in PD mice
Although bradykinesia, tremor and rigidity are the hallmark motor defects in patients with
Parkinson's disease (PD), patients also experience motor learning impairments and non�…
Parkinson's disease (PD), patients also experience motor learning impairments and non�…
[HTML][HTML] What, if, and when to move: basal ganglia circuits and self-paced action initiation
A Klaus, J Alves da Silva…�- Annual review of�…, 2019 - annualreviews.org
Deciding what to do and when to move is vital to our survival. Clinical and fundamental
studies have identified basal ganglia circuits as critical for this process. The main input�…
studies have identified basal ganglia circuits as critical for this process. The main input�…
[HTML][HTML] Distinct cortical-thalamic-striatal circuits through the parafascicular nucleus
The thalamic parafascicular nucleus (PF), an excitatory input to the basal ganglia, is targeted
with deep-brain stimulation to alleviate a range of neuropsychiatric symptoms. Furthermore�…
with deep-brain stimulation to alleviate a range of neuropsychiatric symptoms. Furthermore�…
[HTML][HTML] Striatal synaptic adaptations in Parkinson's disease
The striatum is densely innervated by mesencephalic dopaminergic neurons that modulate
acquisition and vigor of goal-directed actions and habits. This innervation is progressively�…
acquisition and vigor of goal-directed actions and habits. This innervation is progressively�…
Striatal synapses, circuits, and Parkinson's disease
Highlights•Homeostatic plasticity plays an important role in mitigating striatal
pathophysiology in the early stages of PD.•Aberrant dopamine-dependent synaptic plasticity�…
pathophysiology in the early stages of PD.•Aberrant dopamine-dependent synaptic plasticity�…
[HTML][HTML] Striatal glutamatergic hyperactivity in Parkinson's disease
F Campanelli, G Natale, G Marino, V Ghiglieri…�- Neurobiology of�…, 2022 - Elsevier
Glutamatergic hyperactivity in the nucleus striatum, the main basal ganglia input, has been
involved in the progression of Parkinson's disease (PD) and the onset of L-Dopa-induced�…
involved in the progression of Parkinson's disease (PD) and the onset of L-Dopa-induced�…
[HTML][HTML] Cholinergic interneurons amplify thalamostriatal excitation of striatal indirect pathway neurons in Parkinson's disease models
A Tanimura, Y Du, J Kondapalli, DL Wokosin…�- Neuron, 2019 - cell.com
The motor symptoms of Parkinson's disease (PD) are thought to stem from an imbalance in
the activity of striatal direct-and indirect-pathway spiny projection neurons (SPNs). Disease�…
the activity of striatal direct-and indirect-pathway spiny projection neurons (SPNs). Disease�…
[HTML][HTML] The functional organization of cortical and thalamic inputs onto five types of striatal neurons is determined by source and target cell identities
Y Johansson, G Silberberg�- Cell reports, 2020 - cell.com
To understand striatal function, it is essential to know the functional organization of the
numerous inputs targeting the diverse population of striatal neurons. Using optogenetics, we�…
numerous inputs targeting the diverse population of striatal neurons. Using optogenetics, we�…