Recent clinical and preclinical evidence suggests that psychedelics and entactogens may
produce both rapid and sustained therapeutic effects across several indications. Currently�…

The renin‐angiotensin system (RAS) plays essential roles in maintaining peripheral
cardiovascular homeostasis, with its potential roles in the brain only being recognized more�…

MDMA (3, 4-methylenedioxymethamphetamine) is a psychoactive drug with powerful
prosocial effects. While MDMA is sometimes termed an “empathogen,” empirical studies�…

This paper is the forty-fifth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during�…

Opioid use disorder (OUD) is a chronic brain disease which originates from long-term
neuroadaptations that develop after repeated opioid consumption and withdrawal episodes�…

Abstract Alcohol Use Disorder (AUD) is a leading cause of death and disability worldwide,
but current treatments are insufficient in fully addressing the symptoms that often lead to�…

Opioid addiction is characterized by adaptations in the mesolimbic dopamine system that
occur during chronic opioid use. Alterations in dopaminergic transmission contribute to�…

For centuries, ancient lineages have consumed psychedelic compounds from natural
sources. In the modern era, scientists have since harnessed the power of computational�…

Background Chronic opioid exposure leads to hedonic deficits and enhanced vulnerability
to addiction, which are observed and even strengthen after a period of abstinence, but the�…

Aberrant dopamine (DA) signaling is implicated in schizophrenia, bipolar disorder (BPD),
autism spectrum disorder (ASD), substance use disorder, and attention-deficit/hyperactivity�…