Diabetic sensorimotor peripheral neuropathy (DSPN) is a serious complication of diabetes
mellitus and is associated with increased mortality, lower-limb amputations and distressing�…

It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic
required, but also for its major complications, affecting both small and large blood vessels�…

Diabetic peripheral neuropathy (DPN) affects up to 50% of patients with diabetes and is a
major cause of morbidity and increased mortality. Its clinical manifestations include painful�…

Diabetic peripheral neuropathy (DPN) is a common chronic complication of diabetes
mellitus. It leads to distressing and expensive clinical sequelae such as foot ulceration, leg�…

Abstract Purpose of Review The prevalence of diabetes mellitus and its chronic
complications are increasing to epidemic proportions. This will unfortunately result in�…

Neuropathy will afflict over half of the estimated 460 million people worldwide who have
diabetes, 303 of whom approximately onethird will also develop neuropathic pain. 2 The�…

The prevalence of diabetes mellitus and its chronic complications continue to increase
alarmingly. Consequently, the massive expenditure on diabetic distal symmetrical�…

OBJECTIVE Painful diabetic peripheral neuropathy (PDPN) is a common complication of
diabetes mellitus. Unfortunately, pharmacological treatment is often partially effective or�…

Objective. To facilitate the clinician's understanding of the basis and treatment of painful
diabetic neuropathy (PDN). Background. PDN is one of several clinical syndromes in�…

Long-term diabetes increases the likelihood of developing secondary damage to numerous
systems, and these complications represent a substantial cause of morbidity and mortality�…