Our understanding of fragile X syndrome (FXS) pathophysiology continues to improve and
numerous potential drug targets have been identified. Yet, current prescribing practices are�…

Dendritic spines are small protrusions studding neuronal dendrites, first described in 1888
by Ram�n y Cajal using his famous Golgi stainings. Around 50 years later the advance of�…

Although synaptic plasticity in neural circuits is orchestrated by an ocean of genes,
molecules, and proteins, the underlying mechanisms remain poorly understood. Recently, it�…

Fragile X syndrome (FXS) is a monogenic disease caused by mutations in the FMR1 gene.
The Fmr1 knockout (KO) mice show many aspects of FXS-related phenotypes, and have�…

Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by mutations in the
FMR1 gene and deficiency of a functional FMRP protein. FMRP is known as a translation�…

Silencing of the fragile X mental retardation 1 (FMR1) gene and consequently lack of
synthesis of FMR protein (FMRP) are associated with fragile X syndrome, which is one of the�…

Abstract Fragile X Mental Retardation protein (FMRP), widely known for its role in hereditary
intellectual disability, is an RNA‐binding protein (RBP) that controls translation of select�…

Autism spectrum disorder (ASD) is a neurodevelopmental disorder mainly characterized by
social-communication impairments, repetitive behaviors and altered sensory perception�…

The Fragile X syndrome (FXS) is the most frequent form of inherited mental disability and is
considered a monogenic cause of autism spectrum disorder. FXS is caused by a triplet�…

The development and commercialization of new drugs is an articulated, lengthy, and very
expensive process that proceeds through several steps, starting from target identification�…