Timing is critical to most forms of learning, behavior, and sensory-motor processing.
Converging evidence supports the notion that, precisely because of its importance across a�…

The medial prefrontal cortex (mPFC) is a crucial cortical region that integrates information
from numerous cortical and subcortical areas and converges updated information to output�…

Impaired function in the medial prefrontal cortex (mPFC) contributes to depression, and the
therapeutic response produced by novel rapid-acting antidepressants such as ketamine are�…

The medial prefrontal cortex (mPFC) steers goal-directed actions and withholds
inappropriate behavior. Dorsal and ventral mPFC (dmPFC/vmPFC) circuits have distinct�…

Although frontostriatal circuits are critical for the temporal control of action, how time is
encoded in frontostriatal circuits is unknown. We recorded from frontal and striatal neurons�…

Mid-frontal theta activity underlies cognitive control. These 4–8 Hz rhythms are modulated by
cortical dopamine and can be abnormal in patients with Parkinson's disease (PD). Here, we�…

Patients with Parkinson's disease (PD) can have significant cognitive dysfunction; however,
the mechanisms for these cognitive symptoms are unknown. Here, we used scalp�…

The subthalamic nucleus is a key site controlling motor function in humans. Deep brain
stimulation of the subthalamic nucleus can improve movements in patients with Parkinson's�…

Background: Mounting evidence has revealed an inverse association between cigarette
smoking and the risk of Parkinson's disease (PD). Meanwhile, cigarette smoking has been�…

Impulse control and/or gambling disorders can be triggered by dopamine agonist therapies
used to treat Parkinson9s disease, but the cognitive and neurobiological mechanisms�…