Environmental risk factors and biomarkers for autism spectrum disorder: an umbrella review of the evidence

JY Kim, MJ Son, CY Son, J Radua, M Eisenhut…�- The Lancet�…, 2019 - thelancet.com
Background Numerous studies have identified potential risk factors and biomarkers for
autism spectrum disorder. We aimed to study the strength and validity of the suggested�…

[HTML][HTML] Schizophrenia and influenza at the centenary of the 1918-1919 Spanish influenza pandemic: mechanisms of psychosis risk

AP Kępińska, CO Iyegbe, AC Vernon, R Yolken…�- Frontiers in�…, 2020 - frontiersin.org
Associations between influenza infection and psychosis have been reported since the
eighteenth century, with acute “psychoses of influenza” documented during multiple�…

[HTML][HTML] Immune dysfunction and autoimmunity as pathological mechanisms in autism spectrum disorders

HK Hughes, E Mills Ko, D Rose…�- Frontiers in cellular�…, 2018 - frontiersin.org
Autism spectrum disorders (ASD) are a group of heterogeneous neurological disorders that
are highly variable and are clinically characterized by deficits in social interactions�…

[HTML][HTML] Inflammatory mediators drive neuroinflammation in autism spectrum disorder and cerebral palsy

UTT Than, LT Nguyen, PH Nguyen, XH Nguyen…�- Scientific Reports, 2023 - nature.com
Inflammation conditions are associated with autism spectrum disorder (ASD) and cerebral
palsy (CP), primarily observed in the peripheral immune system. However, the extent of�…

[HTML][HTML] Altered behavior, brain structure, and neurometabolites in a rat model of autism-specific maternal autoantibody exposure

MR Bruce, ACM Couch, S Grant, J McLellan, K Ku…�- Molecular�…, 2023 - nature.com
Maternal immune dysregulation is a prenatal risk factor for autism spectrum disorder (ASD).
Importantly, a clinically relevant connection exists between inflammation and metabolic�…

[HTML][HTML] Risk assessment analysis for maternal autoantibody-related autism (MAR-ASD): a subtype of autism

A Ramirez-Celis, M Becker, M Nu�o, J Schauer…�- Molecular�…, 2021 - nature.com
The incidence of autism spectrum disorder (ASD) has been rising, however ASD-risk
biomarkers remain lacking. We previously identified the presence of maternal�…

Prenatal stress, maternal immune dysregulation, and their association with autism spectrum disorders

DQ Beversdorf, HE Stevens, KL Jones�- Current psychiatry reports, 2018 - Springer
Abstract Purpose of Review While genetic factors are a major etiological contributor to
autism spectrum disorder (ASD), evidence also supports a role for environmental factors�…

[HTML][HTML] Repetitive restricted behaviors in autism spectrum disorder: From mechanism to development of therapeutics

J Tian, X Gao, L Yang�- Frontiers in neuroscience, 2022 - frontiersin.org
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized
by deficits in social communication, social interaction, and repetitive restricted behaviors�…

Immune regulation of neurodevelopment at the mother–foetus interface: the case of autism

S Sotgiu, S Manca, A Gagliano…�- Clinical &�…, 2020 - Wiley Online Library
Autism spectrum disorder (ASD) is a neurodevelopmental disorder defined by deficits in
social communication and stereotypical behaviours. ASD's aetiology remains mostly�…

Maternal autoantibody related autism: mechanisms and pathways

KL Jones, J Van de Water�- Molecular psychiatry, 2019 - nature.com
It has been estimated that autism spectrum disorder (ASD) now affects 1 in 59 children in the
United States. Although the cause (s) of ASD remain largely unknown, it is becoming�…