[HTML][HTML] Where, when, and how: context-dependent functions of RNA methylation writers, readers, and erasers
Cellular RNAs are naturally decorated with a variety of chemical modifications. The
structural diversity of the modified nucleosides provides regulatory potential to sort groups of�…
structural diversity of the modified nucleosides provides regulatory potential to sort groups of�…
Biological roles of adenine methylation in RNA
K Boulias, EL Greer�- Nature Reviews Genetics, 2023 - nature.com
Abstract N 6-Methyladenosine (m6A) is one of the most abundant modifications of the
epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in�…
epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in�…
[HTML][HTML] m6A modification: recent advances, anticancer targeted drug discovery and beyond
LJ Deng, WQ Deng, SR Fan, MF Chen, M Qi, WY Lyu…�- Molecular cancer, 2022 - Springer
Abstract Abnormal N6-methyladenosine (m6A) modification is closely associated with the
occurrence, development, progression and prognosis of cancer, and aberrant m6A�…
occurrence, development, progression and prognosis of cancer, and aberrant m6A�…
m6A RNA methylation: from mechanisms to therapeutic potential
RNA carries a diverse array of chemical modifications that play important roles in the
regulation of gene expression. N 6‐methyladenosine (m6A), installed onto mRNA by the�…
regulation of gene expression. N 6‐methyladenosine (m6A), installed onto mRNA by the�…
[HTML][HTML] The proteins of mRNA modification: writers, readers, and erasers
MN Flamand, M Tegowski…�- Annual review of�…, 2023 - annualreviews.org
Over the past decade, mRNA modifications have emerged as important regulators of gene
expression control in cells. Fueled in large part by the development of tools for detecting�…
expression control in cells. Fueled in large part by the development of tools for detecting�…
[HTML][HTML] Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia
FTO, an mRNA N 6-methyladenosine (m 6 A) demethylase, was reported to promote
leukemogenesis. Using structure-based rational design, we have developed two promising�…
leukemogenesis. Using structure-based rational design, we have developed two promising�…
The Critical Role of RNA m6A Methylation in Cancer
Since the identification of the first RNA demethylase and the establishment of methylated
RNA immunoprecipitation-sequencing methodology 6 to 7 years ago, RNA methylation has�…
RNA immunoprecipitation-sequencing methodology 6 to 7 years ago, RNA methylation has�…
[HTML][HTML] Insights into N6-methyladenosine and programmed cell death in cancer
L Liu, H Li, D Hu, Y Wang, W Shao, J Zhong, S Yang…�- Molecular cancer, 2022 - Springer
Abstract N6-methyladenosine (m6A) methylation, the most common form of internal RNA
modification in eukaryotes, has gained increasing attention and become a hot research topic�…
modification in eukaryotes, has gained increasing attention and become a hot research topic�…
[HTML][HTML] Differential m6A, m6Am, and m1A demethylation mediated by FTO in the cell nucleus and cytoplasm
FTO, the first RNA demethylase discovered, mediates the demethylation of internal N 6-
methyladenosine (m 6 A) and N 6, 2-O-dimethyladenosine (m 6 A m) at the+ 1 position from�…
methyladenosine (m 6 A) and N 6, 2-O-dimethyladenosine (m 6 A m) at the+ 1 position from�…
The Emerging Roles of RNA m6A Methylation and Demethylation as Critical Regulators of Tumorigenesis, Drug Sensitivity, and Resistance
Q Lan, PY Liu, JL Bell, JY Wang, S H�ttelmaier…�- Cancer research, 2021 - AACR
Abstract RNA N6-methyladenosine (m6A) modification occurs in approximately 25% of
mRNAs at the transcriptome-wide level. RNA m6A is regulated by the RNA m6A�…
mRNAs at the transcriptome-wide level. RNA m6A is regulated by the RNA m6A�…