Introduction The neurodevelopmental disorder fragile X syndrome (FXS) is the most
common monogenic cause of intellectual disability associated with autism spectrum�…

Synaptic dysfunction underlies many neurodevelopmental disorders (NDDs). The
membrane-associated mucin domain-containing glycosylphosphatidylinositol anchor�…

Fragile X syndrome (FXS) is the single most common monogenetic cause of autism
spectrum disorders (ASDs) in humans. FXS is caused by loss of expression of the fragile X�…

In fragile X syndrome (FXS) the lack of the fragile X mental retardation protein (FMRP) leads
to exacerbated signaling through the metabotropic glutamate receptors 5 (mGlu5Rs). The�…

Despite sustained efforts to treat neurodegenerative diseases, little is known at the
molecular level to understand and generate novel therapeutic approaches for these�…

Autism spectrum disorder is a complex neurodevelopmental condition with genetic and
phenotypic heterogeneity characterized by hallmark impairments in social functioning and�…

Autism spectrum disorders (ASD) are subdivided into idiopathic (unknown) etiology and
secondary, based on known etiology. There are hundreds of causes of ASD and most of�…

Fragile X encompasses a range of genetic conditions, all of which result as a function of
changes within the FMR1 gene and abnormal production and/or expression of the FMR1�…

Amyotrophic lateral sclerosis (ALS) is a fatal, adult-onset neurodegenerative disorder
characterized by progressive muscular weakness due to the selective loss of motor neurons�…

The loss of fragile X mental retardation protein (FMRP) causes fragile X syndrome (FXS), the
most common inherited intellectual disability. How the loss of FMRP alters protein�…