Cerebral plasticity: Windows of opportunity in the developing brain
Background Neuroplasticity refers to the inherently dynamic biological capacity of the central
nervous system (CNS) to undergo maturation, change structurally and functionally in�…
nervous system (CNS) to undergo maturation, change structurally and functionally in�…
[HTML][HTML] Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications
CC Jiang, LS Lin, S Long, XY Ke, K Fukunaga…�- Signal transduction and�…, 2022 - nature.com
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known�…
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known�…
Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders
R Gao, P Penzes�- Current molecular medicine, 2015 - ingentaconnect.com
Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with
complex genetic architectures but overlapping behavioral phenotypes, which suggests�…
complex genetic architectures but overlapping behavioral phenotypes, which suggests�…
Autistic-like behaviour in Scn1a+/− mice and rescue by enhanced GABA-mediated neurotransmission
Haploinsufficiency of the SCN1A gene encoding voltage-gated sodium channel NaV1. 1
causes Dravet's syndrome, a childhood neuropsychiatric disorder including recurrent�…
causes Dravet's syndrome, a childhood neuropsychiatric disorder including recurrent�…
Fragile X syndrome
RJ Hagerman, E Berry-Kravis, HC Hazlett…�- Nature reviews Disease�…, 2017 - nature.com
Fragile X syndrome (FXS) is the leading inherited form of intellectual disability and autism
spectrum disorder, and patients can present with severe behavioural alterations, including�…
spectrum disorder, and patients can present with severe behavioural alterations, including�…
Gephyrin: a master regulator of neuronal function?
SK Tyagarajan, JM Fritschy�- Nature Reviews Neuroscience, 2014 - nature.com
The neurotransmitters GABA and glycine mediate fast synaptic inhibition by activating ligand-
gated chloride channels—namely, type A GABA (GABAA) and glycine receptors. Both types�…
gated chloride channels—namely, type A GABA (GABAA) and glycine receptors. Both types�…
[HTML][HTML] Autism spectrum disorder in the scope of tactile processing
Sensory processing abnormalities are among the most common behavioral phenotypes
seen in autism spectrum disorder (ASD), typically characterized by either over-or under�…
seen in autism spectrum disorder (ASD), typically characterized by either over-or under�…
[HTML][HTML] The GABAA receptor as a therapeutic target for neurodevelopmental disorders
S Braat, RF Kooy�- Neuron, 2015 - cell.com
Intellectual disability, autism spectrum disorder, and epilepsy are prime examples of
neurodevelopmental disorders that collectively affect a significant percentage of the world�…
neurodevelopmental disorders that collectively affect a significant percentage of the world�…
[HTML][HTML] Inhibitory control of the excitatory/inhibitory balance in psychiatric disorders
Neuronal networks consist of different types of neurons that all play their own role in order to
maintain proper network function. The two main types of neurons segregate in excitatory and�…
maintain proper network function. The two main types of neurons segregate in excitatory and�…
[HTML][HTML] GABAergic signaling as therapeutic target for autism spectrum disorders
G Cellot, E Cherubini�- Frontiers in pediatrics, 2014 - frontiersin.org
γ-Aminobutyric acid (GABA), the main inhibitory neurotransmitter in the adult brain, early in
postnatal life exerts a depolarizing and excitatory action. This depends on accumulation of�…
postnatal life exerts a depolarizing and excitatory action. This depends on accumulation of�…