[HTML][HTML] Thioredoxin 1 and Thioredoxin Reductase 1 Redox System Is Dysregulated in Neutrophils of Subjects with Autism: In Vitro Effects of Environmental Toxicant�…

S Alshehri, SF Ahmad, NA Albekairi, SS Alqarni…�- Toxics, 2023 - mdpi.com
Autism spectrum disorder (ASD) is a complex developmental disorder in children that results
in abnormal communicative and verbal behaviors. Exposure to heavy metals plays a�…

[HTML][HTML] Structural insights into the functional mechanism of the ubiquitin ligase E6AP

Z Wang, F Fan, Z Li, F Ye, Q Wang, R Gao, J Qiu…�- Nature�…, 2024 - nature.com
E6AP dysfunction is associated with Angelman syndrome and Autism spectrum disorder.
Additionally, the host E6AP is hijacked by the high-risk HPV E6 to aberrantly ubiquitinate the�…

Lotusine ameliorates propionic acid‐induced autism spectrum disorder‐like behavior in mice by activating D1 dopamine receptor in medial prefrontal cortex

Q Liu, J Mi, Y Du, Z Rong, Y Qin, W Jiang…�- Phytotherapy�…, 2024 - Wiley Online Library
Autism spectrum disorder (ASD) is a multifaceted neuropsychiatric condition for which
effective drug therapy for core clinical symptoms remains elusive. Lotusine, known for its�…

[HTML][HTML] Increased gene dosage of RFWD2 causes autistic-like behaviors and aberrant synaptic formation and function in mice

YX Li, ZN Tan, XH Li, B Ma, F Adu Nti, XQ Lv…�- Molecular�…, 2024 - nature.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by
impaired social interactions, communication deficits and repetitive behaviors. A study of�…

Epigenetic modulators provide a path to understanding disease and therapeutic opportunity

MA Honer, BI Ferman, ZH Gray…�- Genes &�…, 2024 - genesdev.cshlp.org
The discovery of epigenetic modulators (writers, erasers, readers, and remodelers) has shed
light on previously underappreciated biological mechanisms that promote diseases. With�…

[HTML][HTML] Gephyrin phosphorylation facilitates sexually dimorphic development and function of parvalbumin interneurons in the mouse hippocampus

BFN Campbell, N Cruz-Ochoa, K Otomo…�- Molecular�…, 2024 - nature.com
The precise function of specialized GABAergic interneuron subtypes is required to provide
appropriate synaptic inhibition for regulating principal neuron excitability and�…

Is tuberous sclerosis complex-associated autism a preventable and treatable disorder?

P Curatolo, M Scheper, L Emberti Gialloreti…�- World Journal of�…, 2024 - Springer
Background Tuberous sclerosis complex (TSC) is a genetic disorder caused by inactivating
mutations in the TSC1 and TSC2 genes, causing overactivation of the mechanistic�…

[HTML][HTML] Cytokine Dynamics in Autism: Analysis of BMAC Therapy Outcomes

DM Maric, D Vojvodic, DL Maric, G Velikic…�- International Journal of�…, 2023 - mdpi.com
Autism spectrum disorder (ASD) has recently been linked to neuroinflammation and an
aberrant immune response within the central nervous system. The intricate relationship�…

Current and future applications of light-sheet imaging for identifying molecular and developmental processes in autism spectrum disorders

A Soumier, G Lio, C Demily�- Molecular Psychiatry, 2024 - nature.com
Autism spectrum disorder (ASD) is identified by a set of neurodevelopmental divergences
that typically affect the social communication domain. ASD is also characterized by�…

Targeting epigenetic dysregulation in autism spectrum disorders

ML Herrera, J Para�so-Luna, I Bustos-Mart�nez…�- Trends in Molecular�…, 2024 - cell.com
Autism spectrum disorders (ASD) comprise a range of neurodevelopmental pathologies
characterized by deficits in social interaction and repetitive behaviors, collectively affecting�…