Patients with epilepsy often experience comorbid cognitive and behavioral problems. These
problems are often caused by neurodevelopmental disorders such as autism spectrum�…

Many mutations in autism spectrum disorder (ASD) affect a single allele, indicating a key
role for gene dosage in ASD susceptibility. Recently, haplo-insufficiency of ITGB3, the gene�…

Large spines are stable and important for memory trace formation. The majority of large
spines also contains synaptopodin (SP), an actin-modulating and plasticity-related protein�…

Background Whole-exome sequencing studies have been useful for identifying genes that,
when mutated, affect risk for autism spectrum disorder (ASD). Nonetheless, the association�…

Introduction The neurodevelopmental disorder fragile X syndrome (FXS) is the most
common monogenic cause of intellectual disability associated with autism spectrum�…

Dynamic modification of RNA affords proximal regulation of gene expression triggered by
non-genomic or environmental changes. One such epitranscriptomic alteration in RNA�…

MicroRNAs are an emerging class of synaptic regulators. These small noncoding RNAs post-
transcriptionally regulate gene expression, thereby altering neuronal pathways and shaping�…

Noonan syndrome (NS) and NS with multiple lentigines (NSML) cognitive dysfunction are
linked to SH2 domain-containing protein tyrosine phosphatase-2 (SHP2) gain-of-function�…

Recent evidence has documented the potential roles of histone-modifying enzymes in
autism-spectrum disorder (ASD). Aberrant histone H3 lysine 9 (H3K9) dimethylation�…

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social
and repetitive symptoms. A key feature of ASD is early-life manifestations of symptoms�…