Autism spectrum disorders (ASD) are a group of neurodevelopmental diseases. The cause
of ASD is unknown, but several genetic and non-genetic risk factors have been�…

Autism spectrum disorder (ASD) refers to a series of neurodevelopmental diseases
characterized by two hallmark symptoms, social communication deficits and repetitive�…

Postmortem studies have revealed increased density of excitatory synapses in the brains of
individuals with autism spectrum disorder (ASD), with a putative link to aberrant mTOR�…

Dendritic spines are small protrusions from the dendrite membrane, where contact with
neighboring axons is formed in order to receive synaptic input. Changes in size, shape, and�…

The centrosome provides an intracellular anchor for the cytoskeleton, regulating cell
division, cell migration, and cilia formation. We used spatial proteomics to elucidate protein�…

Neurons use local protein synthesis to support their morphological complexity, which
requires independent control across multiple subcellular compartments up to the level of�…

Localized mRNA translation regulates synapse function and axon maintenance, but how
compartment-specific mRNA repertoires are regulated is largely unknown. We developed an�…

Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by the full mutation as
well as highly localized methylation of the fragile X mental retardation 1 (FMR1) gene on the�…

Microglia are so versatile that they not only provide immune surveillance for central nervous
system, but participate in neural circuitry development, brain blood vessels formation, blood�…

Abstract N6‐methyladenosine (m6A) regulates a variety of physiological processes through
modulation of RNA metabolism. This modification is particularly enriched in the nervous�…