The paper provides an overview of biocosmetics, which has tremendous potential for growth
and is attracting huge business opportunities. It emphasizes the immediate need to replace�…

While human regulatory risk assessment (RA) still largely relies on animal studies, new
approach methodologies (NAMs) based on in vitro, in silico or non-mammalian alternative�…

Abstract Background New Approach Methodologies (NAMs) comprise in silico and in vitro
methods applied as alternative to animal testing. Even though NAMs are already fully�…

Endometriosis is an estrogen-dependent gynecologic illness that has long-term effects on a
woman's fertility, physical health, and overall quality of life. Growing evidence suggests that�…

Background The risk assessment of small particles (including nanoparticles) in products
used in the food chain in the EU falls within the remit of the European Food Safety Authority�…

Grape stems have emerged as a promising natural ingredient in the cosmetics industry due
to their abundance of phenolic compounds, known for their antioxidant and anti�…

Public concern about the impact of endocrine disrupting chemicals (EDCs) on both humans
and the environment is growing steadily. Epidemiologic research provides key information�…

Alternative methods to animal use in toxicology are evolving with new advanced tools and
multilevel approaches, to answer from one side to 3Rs requirements, and on the other side�…

Cosmetic products need to have a proven efficacy combined with a comprehensive
toxicological assessment. Before the current Cosmetic regulation N� 1223/2009, the 7th�…

In silico tools and resources are now used commonly in toxicology and to support the “Next
Generation Risk Assessment”(NGRA) of cosmetics ingredients or materials. This review�…