Almost 60 years have passed since the initial discovery by Hubel and Wiesel that changes
in neuronal activity can elicit developmental rewiring of the central nervous system (CNS)�…

Recent advances suggest that the response of RNA metabolism to stress has an important
role in the pathophysiology of neurodegenerative diseases, particularly amyotrophic lateral�…

Many of the diverse functional consequences of activating group 1 metabotropic glutamate
receptors require translation of pre-existing mRNA near synapses. One of these�…

Fragile X syndrome is the most common inherited form of cognitive deficiency in humans
and perhaps the best-understood single cause of autism. A trinucleotide repeat expansion�…

Activity-dependent translation requires the transport of mRNAs within membraneless protein
assemblies known as neuronal granules from the cell body toward synaptic regions�…

Altered synaptic structure and function is a major hallmark of fragile X syndrome (FXS),
autism spectrum disorders (ASDs), and other intellectual disabilities (IDs), which are�…

Neurons decentralize protein synthesis from the cell body to support the active metabolism
of remote dendritic and axonal compartments. The neuronal RNA transport apparatus�…

Dendritic spines are small, thin, specialized protrusions from neuronal dendrites, primarily
localized in the excitatory synapses. Sophisticated imaging techniques revealed that�…

MicroRNAs (miRNAs) are noncoding RNAs that suppress translation of specific mRNAs. The
miRNA machinery interacts with fragile X mental retardation protein (FMRP), which functions�…

The introduction of high-resolution time lapse imaging and molecular biological tools has
changed dramatically the rate of progress towards the understanding of the complex�…