Rho GTPases in neurodegeneration diseases
J DeGeer, N Lamarche-Vane�- Experimental cell research, 2013 - Elsevier
Rho GTPases are molecular switches that modulate multiple intracellular signaling
processes by means of various effector proteins. As a result, Rho GTPase activities are�…
processes by means of various effector proteins. As a result, Rho GTPase activities are�…
Patterns of positive selection in seven ant genomes
The evolution of ants is marked by remarkable adaptations that allowed the development of
very complex social systems. To identify how ant-specific adaptations are associated with�…
very complex social systems. To identify how ant-specific adaptations are associated with�…
[HTML][HTML] Dysregulation of Rac or Rho elicits death of motor neurons and activation of these GTPases is altered in the G93A mutant hSOD1 mouse model of�…
TR Stankiewicz, C Pena, RJ Bouchard…�- Neurobiology of�…, 2020 - Elsevier
Rho GTPases play a central role in neuronal survival; however, the antagonistic relationship
between Rac and Rho in the regulation of motor neuron survival remains poorly defined. In�…
between Rac and Rho in the regulation of motor neuron survival remains poorly defined. In�…
[HTML][HTML] The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42
AW Oliver, X He, K Borthwick, AJ Donne…�- British journal of�…, 2011 - nature.com
Background: Guanidine exchange factor (GEF)-catalysed activation of Rho proteins such as
Cdc42 has been shown to have a crucial role in cellular transformation, malignant�…
Cdc42 has been shown to have a crucial role in cellular transformation, malignant�…
[HTML][HTML] Global gene expression analysis reveals a link between NDRG1 and vesicle transport
HA Askautrud, E Gjernes, G Gunnes, M Sletten…�- PLoS�…, 2014 - journals.plos.org
N-myc downstream-regulated gene 1 (NDRG1) is induced by cellular stress such as hypoxia
and DNA damage, and in humans, germ line mutations cause Charcot-Marie-Tooth disease�…
and DNA damage, and in humans, germ line mutations cause Charcot-Marie-Tooth disease�…
[HTML][HTML] RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis
M N�szai, K Bellec, Y Yu, A Rom�n-Fern�ndez…�- Elife, 2021 - elifesciences.org
RAS-like (RAL) GTPases function in Wnt signalling-dependent intestinal stem cell
proliferation and regeneration. Whether RAL proteins work as canonical RAS effectors in the�…
proliferation and regeneration. Whether RAL proteins work as canonical RAS effectors in the�…
[HTML][HTML] Analogues of Y27632 increase gap junction communication and suppress the formation of transformed NIH3T3 colonies
L Hampson, XT He, AW Oliver, JA Hadfield…�- British journal of�…, 2009 - nature.com
Background: Constitutive activation of RhoA-dependent RhoA kinase (ROCK) signalling is
known to promote cellular transformation and the ROCK inhibitor Y-27632 has the ability to�…
known to promote cellular transformation and the ROCK inhibitor Y-27632 has the ability to�…
[HTML][HTML] A novel stem loop control element-dependent UGA read-through system without translational selenocysteine incorporation in Drosophila
M Hirosawa-Takamori, D Ossipov…�- The FASEB�…, 2009 - ncbi.nlm.nih.gov
Translational read-through of the UGA stop codon is an evolutionarily conserved feature that
most prominently represents the basis of selenoprotein biosynthesis. It requires a specific cis�…
most prominently represents the basis of selenoprotein biosynthesis. It requires a specific cis�…
RAL GTPases mediate EGFR-driven intestinal stem cell hyperproliferation and tumourigenesis
M N�szai, K Bellec, Y Yu, � Rom�n-Fern�ndez…�- bioRxiv, 2020 - biorxiv.org
RAS-like (RAL) GTPases function in Wnt signalling-dependent intestinal stem cell
proliferation and regeneration. Whether RAL proteins work as canonical RAS effectors in the�…
proliferation and regeneration. Whether RAL proteins work as canonical RAS effectors in the�…
Rac1 is a novel interactor of Drosophila guanine nucleotide exchange factor GEFmeso
S Sundaram�- Molecular and Cellular Biochemistry, 2015 - Springer
Guanine nucleotide exchange factors (GEF) are proteins that regulate the activity of
GTPases by catalysing the exchange of GDP for GTP. In this work, we studied the interaction�…
GTPases by catalysing the exchange of GDP for GTP. In this work, we studied the interaction�…