Autism spectrum disorder: neuropathology and animal models

M Varghese, N Keshav, S Jacot-Descombes…�- Acta�…, 2017 - Springer
Autism spectrum disorder (ASD) has a major impact on the development and social
integration of affected individuals and is the most heritable of psychiatric disorders. An�…

[HTML][HTML] The role of the immune system in autism spectrum disorder

A Meltzer, J Van de Water�- Neuropsychopharmacology, 2017 - nature.com
Autism is a neurodevelopmental disorder characterized by deficits in communication and
social skills as well as repetitive and stereotypical behaviors. While much effort has focused�…

Maternal immune activation and neuropsychiatric illness: a translational research perspective

AS Brown, U Meyer�- American Journal of Psychiatry, 2018 - Am Psychiatric Assoc
Epidemiologic studies, including prospective birth cohort investigations, have implicated
maternal immune activation in the etiology of neuropsychiatric disorders. Maternal infectious�…

[HTML][HTML] Immune dysfunction and autoimmunity as pathological mechanisms in autism spectrum disorders

HK Hughes, E Mills Ko, D Rose…�- Frontiers in cellular�…, 2018 - frontiersin.org
Autism spectrum disorders (ASD) are a group of heterogeneous neurological disorders that
are highly variable and are clinically characterized by deficits in social interactions�…

The number of parvalbumin-expressing interneurons is decreased in the prefrontal cortex in autism

E Hashemi, J Ariza, H Rogers, SC Noctor…�- Cerebral�…, 2017 - academic.oup.com
The cognitive phenotype of autism has been correlated with an altered balance of excitation
to inhibition in the cerebral cortex, which could result from a change in the number, function�…

Autoimmunity, autoantibodies, and autism spectrum disorder

E Edmiston, P Ashwood, J Van de Water�- Biological psychiatry, 2017 - Elsevier
Auism spectrum disorder (ASD) now affects one in 68 births in the United States and is the
fastest growing neurodevelopmental disability worldwide. Alarmingly, for the majority of�…

[HTML][HTML] Altered behavior, brain structure, and neurometabolites in a rat model of autism-specific maternal autoantibody exposure

MR Bruce, ACM Couch, S Grant, J McLellan, K Ku…�- Molecular�…, 2023 - nature.com
Maternal immune dysregulation is a prenatal risk factor for autism spectrum disorder (ASD).
Importantly, a clinically relevant connection exists between inflammation and metabolic�…

Risk factors in autism: Thinking outside the brain

L Matelski, J Van de Water�- Journal of autoimmunity, 2016 - Elsevier
Autism spectrum disorders (ASD) are complex neurodevelopmental conditions that have
been rising markedly in prevalence for the past 30 years, now thought to affect 1 in 68 in the�…

[HTML][HTML] Risk assessment analysis for maternal autoantibody-related autism (MAR-ASD): a subtype of autism

A Ramirez-Celis, M Becker, M Nu�o, J Schauer…�- Molecular�…, 2021 - nature.com
The incidence of autism spectrum disorder (ASD) has been rising, however ASD-risk
biomarkers remain lacking. We previously identified the presence of maternal�…

The role of IL-6 in neurodevelopment after prenatal stress

SB Gumusoglu, RS Fine, SJ Murray, JL Bittle…�- Brain, behavior, and�…, 2017 - Elsevier
Prenatal stress exposure is associated with adverse psychiatric outcomes, including autism
and ADHD, as well as locomotor and social inhibition and anxiety-like behaviors in animal�…