Prefrontal cortex and depression
DA Pizzagalli, AC Roberts�- Neuropsychopharmacology, 2022 - nature.com
The prefrontal cortex (PFC) has emerged as one of the regions most consistently impaired in
major depressive disorder (MDD). Although functional and structural PFC abnormalities�…
major depressive disorder (MDD). Although functional and structural PFC abnormalities�…
New and emerging approaches to treat psychiatric disorders
Psychiatric disorders are highly prevalent, often devastating diseases that negatively impact
the lives of millions of people worldwide. Although their etiological and diagnostic�…
the lives of millions of people worldwide. Although their etiological and diagnostic�…
[HTML][HTML] Clinical, gut microbial and neural effects of a probiotic add-on therapy in depressed patients: a randomized controlled trial
AC Schaub, E Schneider…�- Translational�…, 2022 - nature.com
A promising new treatment approach for major depressive disorder (MDD) targets the
microbiota-gut-brain (MGB) axis, which is linked to physiological and behavioral functions�…
microbiota-gut-brain (MGB) axis, which is linked to physiological and behavioral functions�…
Brain stimulation and brain lesions converge on common causal circuits in neuropsychiatric disease
Damage to specific brain circuits can cause specific neuropsychiatric symptoms.
Therapeutic stimulation to these same circuits may modulate these symptoms. To determine�…
Therapeutic stimulation to these same circuits may modulate these symptoms. To determine�…
The orbitofrontal cortex: reward, emotion and depression
The orbitofrontal cortex in primates including humans is the key brain area in emotion, and
in the representation of reward value and in non-reward, that is not obtaining an expected�…
in the representation of reward value and in non-reward, that is not obtaining an expected�…
[HTML][HTML] The critical relationship between anxiety and depression
NH Kalin�- American Journal of Psychiatry, 2020 - Am Psychiatric Assoc
Anxiety and depressive disorders are among the most common psychiatric illnesses; they
are highly comorbid with each other, and together they are considered to belong to the�…
are highly comorbid with each other, and together they are considered to belong to the�…
Quantifying deviations of brain structure and function in major depressive disorder across neuroimaging modalities
Importance Identifying neurobiological differences between patients with major depressive
disorder (MDD) and healthy individuals has been a mainstay of clinical neuroscience for�…
disorder (MDD) and healthy individuals has been a mainstay of clinical neuroscience for�…
The state of our understanding of the pathophysiology and optimal treatment of depression: glass half full or half empty?
CB Nemeroff�- American Journal of Psychiatry, 2020 - Am Psychiatric Assoc
Major depressive disorder is a remarkably common and often severe psychiatric disorder
associated with high levels of morbidity and mortality. Patients with major depression are�…
associated with high levels of morbidity and mortality. Patients with major depression are�…
A Systematic Evaluation of Machine Learning–Based Biomarkers for Major Depressive Disorder
Importance Biological psychiatry aims to understand mental disorders in terms of altered
neurobiological pathways. However, for one of the most prevalent and disabling mental�…
neurobiological pathways. However, for one of the most prevalent and disabling mental�…
Absence of structural brain changes from mindfulness-based stress reduction: Two combined randomized controlled trials
Studies purporting to show changes in brain structure following the popular, 8-week
mindfulness-based stress reduction (MBSR) course are widely referenced despite major�…
mindfulness-based stress reduction (MBSR) course are widely referenced despite major�…