Epigenetic modulators provide a path to understanding disease and therapeutic opportunity
MA Honer, BI Ferman, ZH Gray…�- Genes &�…, 2024 - genesdev.cshlp.org
The discovery of epigenetic modulators (writers, erasers, readers, and remodelers) has shed
light on previously underappreciated biological mechanisms that promote diseases. With�…
light on previously underappreciated biological mechanisms that promote diseases. With�…
Targeting epigenetic dysregulation in autism spectrum disorders
ML Herrera, J Para�so-Luna, I Bustos-Mart�nez…�- Trends in Molecular�…, 2024 - cell.com
Autism spectrum disorders (ASD) comprise a range of neurodevelopmental pathologies
characterized by deficits in social interaction and repetitive behaviors, collectively affecting�…
characterized by deficits in social interaction and repetitive behaviors, collectively affecting�…
Cancer and neurodevelopmental disorders: multi-scale reasoning and computational guide
The connection and causality between cancer and neurodevelopmental disorders have
been puzzling. How can the same cellular pathways, proteins, and mutations lead to�…
been puzzling. How can the same cellular pathways, proteins, and mutations lead to�…
Gestational hypothyroxinemia induces ASD-like phenotypes in behavior, proinflammatory markers, and glutamatergic protein expression in mouse offspring of both�…
E Gonz�lez-Madrid, MA Rangel-Ram�rez…�- Frontiers in�…, 2024 - frontiersin.org
Background The prevalence of autism spectrum disorder (ASD) has significantly risen in the
past three decades, prompting researchers to explore the potential contributions of�…
past three decades, prompting researchers to explore the potential contributions of�…
[HTML][HTML] Structural insights into the functional mechanism of the ubiquitin ligase E6AP
Z Wang, F Fan, Z Li, F Ye, Q Wang, R Gao, J Qiu…�- Nature�…, 2024 - nature.com
E6AP dysfunction is associated with Angelman syndrome and Autism spectrum disorder.
Additionally, the host E6AP is hijacked by the high-risk HPV E6 to aberrantly ubiquitinate the�…
Additionally, the host E6AP is hijacked by the high-risk HPV E6 to aberrantly ubiquitinate the�…
[HTML][HTML] Loss-of-function variant in spermidine/spermine N1-acetyl transferase like 1 (SATL1) gene as an underlying cause of autism spectrum disorder
AM Alayoubi, M Iqbal, H Aman, JA Hashmi…�- Scientific Reports, 2024 - nature.com
Autism spectrum disorder (ASD) is a complicated, lifelong neurodevelopmental disorder
affecting verbal and non-verbal communication and social interactions. ASD signs and�…
affecting verbal and non-verbal communication and social interactions. ASD signs and�…
Intermittent Hypobaric Hypoxia Ameliorates Autistic-Like Phenotypes in Mice
Y Zhang, W Zheng, M Zhu, H Li, W Ouyang…�- Journal of�…, 2024 - Soc Neuroscience
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by
persistent deficits in social communication and stereotyped behaviors. Although major�…
persistent deficits in social communication and stereotyped behaviors. Although major�…
[HTML][HTML] Increased gene dosage of RFWD2 causes autistic-like behaviors and aberrant synaptic formation and function in mice
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by
impaired social interactions, communication deficits and repetitive behaviors. A study of�…
impaired social interactions, communication deficits and repetitive behaviors. A study of�…
[HTML][HTML] Gephyrin phosphorylation facilitates sexually dimorphic development and function of parvalbumin interneurons in the mouse hippocampus
BFN Campbell, N Cruz-Ochoa, K Otomo…�- Molecular�…, 2024 - nature.com
The precise function of specialized GABAergic interneuron subtypes is required to provide
appropriate synaptic inhibition for regulating principal neuron excitability and�…
appropriate synaptic inhibition for regulating principal neuron excitability and�…
Comprehensive exploration of multi-modal and multi-branch imaging markers for autism diagnosis and interpretation: insights from an advanced deep learning model
Autism spectrum disorder is a complex neurodevelopmental condition with diverse genetic
and brain involvement. Despite magnetic resonance imaging advances, autism spectrum�…
and brain involvement. Despite magnetic resonance imaging advances, autism spectrum�…