Genes associated with risk for brain disease exhibit characteristic expression patterns that
reflect both anatomical and cell type relationships. Brain-wide transcriptomic patterns of�…

Background Mouse models have allowed for the direct interrogation of genetic effects on
molecular, physiological, and behavioral brain phenotypes. However, it is unknown to what�…

INTRODUCTION The brain is responsible for cognition, behavior, and much of what makes
us uniquely human. The development of the brain is a highly complex process, and this�…

Many neurodegenerative diseases have a hallmark regional and cellular pathology. Gene
expression analysis of healthy tissues may provide clues to the differences that distinguish�…

The cerebral cortex underlies many of our unique strengths and vulnerabilities, but efforts to
understand human cortical organization are challenged by reliance on incompatible�…

Noninvasive neuroimaging is a powerful tool for quantifying diverse aspects of brain
structure and function in vivo, and it has been used extensively to map the neural changes�…

Brain function is governed by precise regulation of gene expression across its anatomically
distinct structures; however, the expression patterns of genes across hundreds of brain�…

Background Alzheimer's disease (AD) is the most common form of dementia, characterized
by progressive cognitive impairment and neurodegeneration. However, despite extensive�…

Transcriptional profiles within discrete human brain regions are likely to reflect structural and
functional specialization. Using DNA microarray technology, this study investigates�…

Identifying the molecular programs underlying human organ development and how they
differ from model species is key for understanding human health and disease�…