Despite sustained efforts to treat neurodegenerative diseases, little is known at the
molecular level to understand and generate novel therapeutic approaches for these�…

Short tandem repeat (STR) instability causes transcriptional silencing in several repeat
expansion disorders. In fragile X syndrome (FXS), mutation-length expansion of a CGG STR�…

The application of ambient mass spectrometry imaging “MSI” is expanding in the areas of
fundamental research on drug delivery and multiple phases of the process of identifying and�…

Abstract Fragile X Syndrome (FXS) is a neurodevelopment disorder characterized by
cognitive impairment, behavioral challenges, and synaptic abnormalities, with a genetic�…

Autism spectrum disorder (ASD) has a multifactorial etiology. Major efforts are underway to
understand the neurobiological bases of ASD and to develop efficacious treatment�…

Introduction The neurodevelopmental disorder fragile X syndrome (FXS) is the most
common monogenic cause of intellectual disability associated with autism spectrum�…

Synaptic dysfunction underlies many neurodevelopmental disorders (NDDs). The
membrane-associated mucin domain-containing glycosylphosphatidylinositol anchor�…

Fragile X syndrome (FXS) is the single most common monogenetic cause of autism
spectrum disorders (ASDs) in humans. FXS is caused by loss of expression of the fragile X�…

Amyotrophic lateral sclerosis (ALS) is a fatal, adult-onset neurodegenerative disorder
characterized by progressive muscular weakness due to the selective loss of motor neurons�…

Although KDM5C is one of the most frequently mutated genes in X-linked intellectual
disability, the exact mechanisms that lead to cognitive impairment remain unknown. Here we�…