Disrupted mesocortical dopamine contributes to cognitive symptoms of Parkinson's disease
(PD). Past work has implicated medial frontal neurons expressing D1 dopamine receptors�…

Considerable evidence has shown that prefrontal neurons expressing D1-type dopamine
receptors (D1DRs) are critical for working memory, flexibility, and timing. This line of work�…

Temporal control, or how organisms guide movements in time to achieve behavioral goals,
depends on dopamine signaling. The medial prefrontal cortex controls many goal-directed�…

The dopamine (DA) system plays a major role in cognitive functions through its interactions
with several brain regions including the prefrontal cortex (PFC). Conversely, disturbances in�…

Dopamine modulation in the prefrontal cortex is important for cognitive processing and
disrupted in diverse neuropsychiatric diseases. Activation of D1 receptors is thought to�…

Medial frontal cortical (MFC) dopamine is essential for the organization of behavior in time.
Our prior work indicates that blocking D1 dopamine receptors (D1DR) attenuates temporal�…

Dopaminergic modulation of prefrontal cortex (PFC) is thought to play key roles in many
cognitive functions and to be disrupted in pathological conditions, such as schizophrenia�…

The prefrontal cortex (PFC) is crucial for maintaining relevant information in working memory
and resisting interference. PFC neurons are strongly regulated by dopamine, but it is�…

Although the cardinal features of Parkinson's disease (PD) are motor symptoms, PD also
causes cognitive deficits including cognitive flexibility and working memory, which are�…

The prefrontal cortex (PFC) elaborates and differentiates in primates, and there is a
corresponding elaboration in cortical dopamine (DA). DA cells that fire to both aversive and�…