[HTML][HTML] A neural m6A/Ythdf pathway is required for learning and memory in Drosophila
Epitranscriptomic modifications can impact behavior. Here, we used Drosophila
melanogaster to study N6-methyladenosine (m6A), the most abundant modification of�…
melanogaster to study N6-methyladenosine (m6A), the most abundant modification of�…
[HTML][HTML] Mettl3-dependent m6A modification attenuates the brain stress response in Drosophila
Abstract N 6-methyladenosine (m6A), the most prevalent internal modification on eukaryotic
mRNA, plays an essential role in various stress responses. The brain is uniquely vulnerable�…
mRNA, plays an essential role in various stress responses. The brain is uniquely vulnerable�…
A fly view on the roles and mechanisms of the m6A mRNA modification and its players
ABSTRACT RNA modifications are an emerging layer of posttranscriptional gene regulation
in eukaryotes. N6-methyladenosine (m6A) is among the most abundant modifications in�…
in eukaryotes. N6-methyladenosine (m6A) is among the most abundant modifications in�…
m6A modulates neuronal functions and sex determination in Drosophila
Abstract N 6-methyladenosine RNA (m6A) is a prevalent messenger RNA modification in
vertebrates. Although its functions in the regulation of post-transcriptional gene expression�…
vertebrates. Although its functions in the regulation of post-transcriptional gene expression�…
[HTML][HTML] Ythdf2-mediated m6A mRNA clearance modulates neural development in mice
Abstract Background N 6-methyladenosine (m 6 A) modification in mRNAs was recently
shown to be dynamically regulated, indicating a pivotal role in multiple developmental�…
shown to be dynamically regulated, indicating a pivotal role in multiple developmental�…
[HTML][HTML] Role of Hakai in m6A modification pathway in Drosophila
Y Wang, L Zhang, H Ren, L Ma, J Guo, D Mao…�- Nature�…, 2021 - nature.com
Abstract N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic
mRNA, is installed by a multi-component writer complex; however, the exact roles of each�…
mRNA, is installed by a multi-component writer complex; however, the exact roles of each�…
[HTML][HTML] CG14906 (mettl4) mediates m6A methylation of U2 snRNA in Drosophila
Dear Editor, While the eukaryotic candidate m6A methyltransferases belong to multiple
distinct methylase lineages, the most widespread group belongs to the MT-A70 family�…
distinct methylase lineages, the most widespread group belongs to the MT-A70 family�…
Context-dependent functional compensation between Ythdf m6A reader proteins
L Lasman, V Krupalnik, S Viukov, N Mor…�- Genes &�…, 2020 - genesdev.cshlp.org
Abstract The N6-methyladenosine (m 6 A) modification is the most prevalent post-
transcriptional mRNA modification, regulating mRNA decay and splicing. It plays a major�…
transcriptional mRNA modification, regulating mRNA decay and splicing. It plays a major�…
[HTML][HTML] The m6A pathway facilitates sex determination in Drosophila
The conserved modification N 6-methyladenosine (m6A) modulates mRNA processing and
activity. Here, we establish the Drosophila system to study the m6A pathway. We first apply�…
activity. Here, we establish the Drosophila system to study the m6A pathway. We first apply�…
m6A facilitates hippocampus-dependent learning and memory through YTHDF1
Abstract N 6-methyladenosine (m6A), the most prevalent internal RNA modification on
mammalian messenger RNAs, regulates the fates and functions of modified transcripts�…
mammalian messenger RNAs, regulates the fates and functions of modified transcripts�…