Background Gender-related differences in humans are commonly observed in behaviour,
physical activity, disease, and lifespan. However, the notion that age-related changes in the�…

Gender and sex are known to be associated with longevity. While males are usually
stronger, females live longer. In the Western world, the life expectancy of individual born�…

Aging is associated with a decline in immune function. Interferon-γ (IFN-γ) and interleukin-4
(IL-4), two important immune deviation-related cytokines, are mainly produced by type 1 and�…

Background: Substantial changes in both representation and function of T lymphocyte
subsets have been reported with advancing age. However, till now, no systematic studies�…

Background Alterations in the number and composition of lymphocytes and their subsets in
blood are considered a hallmark of immune system aging. However, it is unknown whether�…

Background There is reported to be a decline in immune function and an alteration in the
frequency of circulating lymphocytes with advancing age. There are also differences in�…

Cytokine generation by T cells and monocytes was determined for 50 subjects aged 65 yr or
older and concurrently studied young subjects individually matched to each old subject for�…

Peripheral blood mononuclear cells were obtained from people ranging in age from
newborn to 102 years old and analyzed by dual color flow cytometer in terms of number and�…

Several alterations in immune function and a concomitant progressive increase in pro-
inflammatory status are the major characteristics of ageing process. Cytokines play a key�…

The innate and adaptive branches of the immune system display changes with aging, a fact
referred to as immunosenescence. Furthermore, it has been established that adaptive�…