Fragile X mental retardation protein modulates the stability of its m6A-marked messenger RNA targets
Abstract N 6-methyladenosine (m6A) is the most prevalent internal modification of
mammalian messenger RNAs (mRNAs) and long non-coding RNAs. The biological�…
mammalian messenger RNAs (mRNAs) and long non-coding RNAs. The biological�…
[HTML][HTML] The RNA-binding protein FMRP facilitates the nuclear export of N6-methyladenosine–containing mRNAs
N 6-Methyladenosine (m 6 A) is the most abundant post-transcriptional mRNA modification
in eukaryotes and exerts many of its effects on gene expression through reader proteins that�…
in eukaryotes and exerts many of its effects on gene expression through reader proteins that�…
[HTML][HTML] FMRP modulates neural differentiation through m6A-dependent mRNA nuclear export
Summary N 6-methyladenosine (m 6 A) modification of mRNA is emerging as a vital
mechanism regulating RNA function. Here, we show that fragile X mental retardation protein�…
mechanism regulating RNA function. Here, we show that fragile X mental retardation protein�…
The molecular biology of FMRP: new insights into fragile X syndrome
JD Richter, X Zhao�- Nature Reviews Neuroscience, 2021 - nature.com
Fragile X mental retardation protein (FMRP) is the product of the fragile X mental retardation
1 gene (FMR1), a gene that—when epigenetically inactivated by a triplet nucleotide repeat�…
1 gene (FMR1), a gene that—when epigenetically inactivated by a triplet nucleotide repeat�…
[HTML][HTML] The FMRP regulon: from targets to disease convergence
E Fern�ndez, N Rajan, C Bagni�- Frontiers in neuroscience, 2013 - frontiersin.org
The fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates
mRNA metabolism. FMRP has been largely studied in the brain, where the absence of this�…
mRNA metabolism. FMRP has been largely studied in the brain, where the absence of this�…
Novel FMRP interaction networks linked to cellular stress
MS Taha, F Haghighi, A Stefanski…�- The FEBS�…, 2021 - Wiley Online Library
Silencing of the fragile X mental retardation 1 (FMR1) gene and consequently lack of
synthesis of FMR protein (FMRP) are associated with fragile X syndrome, which is one of the�…
synthesis of FMR protein (FMRP) are associated with fragile X syndrome, which is one of the�…
Methylation regulates the intracellular protein-protein and protein-RNA interactions of FMRP
N Dolzhanskaya, G Merz, JM Aletta…�- Journal of cell�…, 2006 - journals.biologists.com
FMRP, the fragile X mental retardation protein, is an RNA-binding protein that interacts
with∼ 4% of fetal brain mRNA. We have recently shown that a methyltransferase (MT) co�…
with∼ 4% of fetal brain mRNA. We have recently shown that a methyltransferase (MT) co�…
A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies
Fragile X syndrome (FXS) is caused by the loss of fragile X mental retardation protein
(FMRP), an RNA-binding protein that can regulate the translation of specific mRNAs. In this�…
(FMRP), an RNA-binding protein that can regulate the translation of specific mRNAs. In this�…
Regulatory discrimination of mRNAs by FMRP controls mouse adult neural stem cell differentiation
Fragile X syndrome (FXS) is caused by the loss of fragile X mental retardation protein
(FMRP), an RNA binding protein whose deficiency impacts many brain functions, including�…
(FMRP), an RNA binding protein whose deficiency impacts many brain functions, including�…
[HTML][HTML] Widespread alterations in translation elongation in the brain of juvenile Fmr1 knockout mice
SD Sharma, JB Metz, H Li, BD Hobson, N Hornstein…�- Cell reports, 2019 - cell.com
FMRP (fragile X mental retardation protein) is a polysome-associated RNA-binding protein
encoded by Fmr1 that is lost in fragile X syndrome. Increasing evidence suggests that FMRP�…
encoded by Fmr1 that is lost in fragile X syndrome. Increasing evidence suggests that FMRP�…