Ras signaling mechanisms underlying impaired GluR1-dependent plasticity associated with fragile X syndrome
H Hu, Y Qin, G Bochorishvili, Y Zhu…�- Journal of�…, 2008 - Soc Neuroscience
Fragile X syndrome, caused by the loss of FMR1 gene function and loss of fragile X mental
retardation protein (FMRP), is the most commonly inherited form of mental retardation. The�…
retardation protein (FMRP), is the most commonly inherited form of mental retardation. The�…
New perspectives on the biology of fragile X syndrome
Fragile X syndrome (FXS) is a trinucleotide repeat disorder caused by a CGG repeat
expansion in FMR1, and loss of its protein product FMRP. Recent studies have provided�…
expansion in FMR1, and loss of its protein product FMRP. Recent studies have provided�…
[HTML][HTML] Fragile x syndrome and autism: from disease model to therapeutic targets
Autism is an umbrella diagnosis with several different etiologies. Fragile X syndrome (FXS),
one of the first identified and leading causes of autism, has been modeled in mice using�…
one of the first identified and leading causes of autism, has been modeled in mice using�…
Neuroanatomical, molecular genetic, and behavioral correlates of fragile X syndrome
SD Koukoui, A Chaudhuri�- Brain research reviews, 2007 - Elsevier
Fragile X syndrome (FXS) is a leading cause of inherited mental retardation. In the vast
majority of cases, this X-linked disorder is due to a CGG expansion in the 5′ untranslated�…
majority of cases, this X-linked disorder is due to a CGG expansion in the 5′ untranslated�…
Alterations in CA1 hippocampal synapses in a mouse model of fragile X syndrome
Abstract Fragile X Syndrome (FXS) is the major cause of inherited mental retardation and
the leading genetic cause of Autism spectrum disorders. FXS is caused by mutations in the�…
the leading genetic cause of Autism spectrum disorders. FXS is caused by mutations in the�…
Selective deletion of astroglial FMRP dysregulates glutamate transporter GLT1 and contributes to fragile X syndrome phenotypes in vivo
H Higashimori, CS Schin, MSR Chiang…�- Journal of�…, 2016 - Soc Neuroscience
How the loss of fragile X mental retardation protein (FMRP) in different brain cell types,
especially in non-neuron glial cells, induces fragile X syndrome (FXS) phenotypes has just�…
especially in non-neuron glial cells, induces fragile X syndrome (FXS) phenotypes has just�…
Fragile X mental retardation protein in learning-related synaptic plasticity
V Mercaldo, G Descalzi, M Zhuo�- Molecules and cells, 2009 - Springer
Fragile X syndrome (FXS) is caused by a lack of the fragile X mental retardation protein
(FMRP) due to silencing of the Fmr1 gene. As an RNA binding protein, FMRP is thought to�…
(FMRP) due to silencing of the Fmr1 gene. As an RNA binding protein, FMRP is thought to�…
Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome
Fragile X syndrome (FXS) is an inherited neurologic disease caused by loss of fragile X
mental retardation protein (FMRP), which is hypothesized to mediate negative regulation of�…
mental retardation protein (FMRP), which is hypothesized to mediate negative regulation of�…
Integrative analysis identifies key molecular signatures underlying neurodevelopmental deficits in fragile X syndrome
Abstract Background Fragile X syndrome (FXS) is a neurodevelopmental disorder caused
by epigenetic silencing of FMR1 and loss of FMRP expression. Efforts to understand the�…
by epigenetic silencing of FMR1 and loss of FMRP expression. Efforts to understand the�…
[HTML][HTML] Altered neuronal and circuit excitability in fragile X syndrome
A Contractor, VA Klyachko, C Portera-Cailliau�- Neuron, 2015 - cell.com
Fragile X syndrome (FXS) results from a genetic mutation in a single gene yet produces a
phenotypically complex disorder with a range of neurological and psychiatric problems�…
phenotypically complex disorder with a range of neurological and psychiatric problems�…