Recent studies suggest an association of dopamine D2 receptor (DRD2) availability with
flexibility in reward-based learning. We extend these results by demonstrating an�…

Genetic and pharmacological studies suggest an important role of the dopamine D2
receptor (DRD2) in flexible behavioral adaptation, mostly shown in reward-based learning�…

Dopamine plays an important role in action selection, but little is known about the influence
of different dopamine receptor systems on the subprocesses occurring during the cascading�…

In humans, presence of an A1 allele of the DRD2/ANKK1-TaqIa polymorphism is associated
with reduced expression of dopamine (DA) D2 receptors in the striatum. Recently, it was�…

Individuals differ in their tendencies to seek positive decision outcomes or to avoid negative
ones. At the neurobiological level, our model suggests that phasic changes in dopamine�…

Background Variation of the gene coding for D2 receptors (DRD2) has been associated with
risk for schizophrenia and with working memory deficits. A functional intronic SNP�…

Cognitive flexibility, the ability to adapt goal‐oriented behaviour in response to changing
environmental demands, varies widely amongst individuals, yet its underlying neural�…

Dopamine modulation in the prefrontal cortex is important for cognitive processing and
disrupted in diverse neuropsychiatric diseases. Activation of D1 receptors is thought to�…

Deviations in reward sensitivity and behavioral flexibility, particularly in the ability to change
or stop behaviors in response to changing environmental contingencies, are important�…

The dopamine D2 and D3 receptors are implicated in schizophrenia and its
pharmacological treatments. These receptors undergo intracellular trafficking processes that�…