Autism: maternally derived antibodies specific for fetal brain proteins

D Braunschweig, P Ashwood, P Krakowiak…�- Neurotoxicology, 2008 - Elsevier
Autism is a profound disorder of neurodevelopment with poorly understood biological
origins. A potential role for maternal autoantibodies in the etiology of some cases of autism�…

Maternal antibrain antibodies in autism

AW Zimmerman, SL Connors, KJ Matteson…�- Brain, behavior, and�…, 2007 - Elsevier
Autism is a neurodevelopmental disorder of prenatal onset that is behaviorally defined.
There is increasing evidence for systemic and neuroimmune mechanisms in children with�…

Antibodies against fetal brain in sera of mothers with autistic children

HS Singer, CM Morris, CD Gause, PK Gillin…�- Journal of�…, 2008 - Elsevier
Serum antibodies in 100 mothers of children with autistic disorder (MCAD) were compared
to 100 age-matched mothers with unaffected children (MUC) using as antigenic substrates�…

Maternal mid-pregnancy autoantibodies to fetal brain protein: the early markers for autism study

LA Croen, D Braunschweig, L Haapanen…�- Biological�…, 2008 - Elsevier
BACKGROUND: Immune dysfunction has been associated with autism, yet whether
maternal immune status during pregnancy plays a causal role remains to be clarified�…

Autoantibodies to cerebellum in children with autism associate with behavior

P Goines, L Haapanen, R Boyce, P Duncanson…�- Brain, behavior, and�…, 2011 - Elsevier
Autism is a heterogeneous disorder with a poorly understood biological basis. Some
children with autism harbor plasma autoantibodies that target brain proteins. Similarly, some�…

Behavioral correlates of maternal antibody status among children with autism

D Braunschweig, P Duncanson, R Boyce…�- Journal of autism and�…, 2012 - Springer
Autism spectrum disorders (ASDs) affect approximately 1 in 110 children in the United
States. This report profiles fetal-brain reactive autoantibodies of a large cohort of mothers of�…

[HTML][HTML] Maternal antibodies from mothers of children with autism alter brain growth and social behavior development in the rhesus monkey

MD Bauman, AM Iosif, P Ashwood…�- Translational�…, 2013 - nature.com
Antibodies directed against fetal brain proteins of 37 and 73 kDa molecular weight are found
in approximately 12% of mothers who have children with autism spectrum disorder (ASD)�…

Prenatal exposure to autism-specific maternal autoantibodies alters proliferation of cortical neural precursor cells, enlarges brain, and increases neuronal size in adult�…

V Mart�nez-Cerde�o, J Camacho, E Fox, E Miller…�- Cerebral�…, 2016 - academic.oup.com
Autism spectrum disorders (ASDs) affect up to 1 in 68 children. Autism-specific
autoantibodies directed against fetal brain proteins have been found exclusively in a�…

Brain-reactive IgG correlates with autoimmunity in mothers of a child with an autism spectrum disorder

L Brimberg, A Sadiq, PK Gregersen, B Diamond�- Molecular psychiatry, 2013 - nature.com
It is believed that in utero environmental factors contribute to autism spectrum disorder
(ASD). The goal of this study was to demonstrate, using the largest cohort reported so far�…

Maternal and fetal antibrain antibodies in development and disease

E Fox, D Amaral, J Van de Water�- Developmental�…, 2012 - Wiley Online Library
Recent evidence has emerged indicating that the maternal immune response can have a
substantial deleterious impact on prenatal development (Croen et al.,[2008]: Biol Psychiatry�…