Maternal immune activation and autism spectrum disorder: from rodents to nonhuman and human primates

M Careaga, T Murai, MD Bauman�- Biological psychiatry, 2017 - Elsevier
A subset of women who are exposed to infection during pregnancy have an increased risk of
giving birth to a child who will later be diagnosed with a neurodevelopmental or�…

Activation of the maternal immune system alters cerebellar development in the offspring

L Shi, SEP Smith, N Malkova, D Tse, Y Su…�- Brain, behavior, and�…, 2009 - Elsevier
A common pathological finding in autism is a localized deficit in Purkinje cells (PCs).
Cerebellar abnormalities have also been reported in schizophrenia. Using a mouse model�…

Neuropathology and animal models of autism: genetic and environmental factors

BS Gadad, L Hewitson, KA Young…�- Autism research and�…, 2013 - Wiley Online Library
Autism is a heterogeneous behaviorally defined neurodevelopmental disorder. It is defined
by the presence of marked social deficits, specific language abnormalities, and stereotyped�…

Maternal immune activation and autism spectrum disorder: interleukin-6 signaling as a key mechanistic pathway

EC Parker-Athill, J Tan�- Neurosignals, 2011 - karger.com
An emerging area of research in autism spectrum disorder (ASD) is the role of prenatal
exposure to inflammatory mediators during critical developmental periods. Epidemiological�…

Peripheral and central inflammation in autism spectrum disorders

AM Depino�- Molecular and Cellular Neuroscience, 2013 - Elsevier
Recent reports have given a central role to environmental factors in the etiology of autism
spectrum disorders (ASD). However, most proposed perinatal factors seem to converge into�…

[HTML][HTML] Brain changes in a maternal immune activation model of neurodevelopmental brain disorders

L Bergdolt, A Dunaevsky�- Progress in neurobiology, 2019 - Elsevier
The developing brain is sensitive to a variety of insults. Epidemiological studies have
identified prenatal exposure to infection as a risk factor for a range of neurological disorders�…

Maternal immune activation causes age-and region-specific changes in brain cytokines in offspring throughout development

PA Garay, EY Hsiao, PH Patterson…�- Brain, behavior, and�…, 2013 - Elsevier
Maternal infection is a risk factor for autism spectrum disorder (ASD) and schizophrenia (SZ).
Indeed, modeling this risk factor in mice through maternal immune activation (MIA) causes�…

[HTML][HTML] Further characterization of autoantibodies to GABAergic neurons in the central nervous system produced by a subset of children with autism

S Wills, CC Rossi, J Bennett, V Martinez-Cerde�o…�- Molecular autism, 2011 - Springer
Background Autism is a neurodevelopmental disorder characterized by impairments in
social interaction and deficits in verbal and nonverbal communication, together with the�…

Effects of prenatal infection on brain development and behavior: a review of findings from animal models

P Boksa�- Brain, behavior, and immunity, 2010 - Elsevier
Epidemiological studies with human populations indicate associations between maternal
infection during pregnancy and increased risk in offspring for central nervous system (CNS)�…

[HTML][HTML] Maternal immune dysregulation and autism–understanding the role of cytokines, chemokines and autoantibodies

J McLellan, DHJ Kim, M Bruce, A Ramirez-Celis…�- Frontiers in�…, 2022 - frontiersin.org
Autism spectrum disorder (ASD) is acknowledged as a highly heterogeneous, behaviorally
defined neurodevelopmental disorder with multiple etiologies. In addition to its high�…