Prenatal exposure to antibodies from mothers of children with autism produces neurobehavioral alterations: a pregnant dam mouse model
HS Singer, C Morris, C Gause, M Pollard…�- Journal of�…, 2009 - Elsevier
A pregnant mouse model was used to compare the effect of IgG, administered E13-E18,
from mothers of children with autistic disorder (MCAD), to controls (simple-and IgG-) on�…
from mothers of children with autistic disorder (MCAD), to controls (simple-and IgG-) on�…
Maternal autism-associated IgG antibodies delay development and produce anxiety in a mouse gestational transfer model
D Braunschweig, MS Golub, CM Koenig, L Qi…�- Journal of�…, 2012 - Elsevier
A murine passive transfer model system was employed to ascertain the effects of gestational
exposure to a single, intravenous dose of purified, brain-reactive IgG antibodies from�…
exposure to a single, intravenous dose of purified, brain-reactive IgG antibodies from�…
[HTML][HTML] Maternal antibodies from mothers of children with autism alter brain growth and social behavior development in the rhesus monkey
Antibodies directed against fetal brain proteins of 37 and 73 kDa molecular weight are found
in approximately 12% of mothers who have children with autism spectrum disorder (ASD)�…
in approximately 12% of mothers who have children with autism spectrum disorder (ASD)�…
Maternal antibrain antibodies in autism
AW Zimmerman, SL Connors, KJ Matteson…�- Brain, behavior, and�…, 2007 - Elsevier
Autism is a neurodevelopmental disorder of prenatal onset that is behaviorally defined.
There is increasing evidence for systemic and neuroimmune mechanisms in children with�…
There is increasing evidence for systemic and neuroimmune mechanisms in children with�…
Embryonic intraventricular exposure to autism-specific maternal autoantibodies produces alterations in autistic-like stereotypical behaviors in offspring mice
J Camacho, K Jones, E Miller, J Ariza, S Noctor…�- Behavioural brain�…, 2014 - Elsevier
Multiple studies have implicated a role of maternal autoantibodies reactive against fetal
brain proteins specific to autism in the etiology of autism spectrum disorders (ASD). In the�…
brain proteins specific to autism in the etiology of autism spectrum disorders (ASD). In the�…
Stereotypies and hyperactivity in rhesus monkeys exposed to IgG from mothers of children with autism
LA Martin, P Ashwood, D Braunschweig…�- Brain, behavior, and�…, 2008 - Elsevier
Autism together with Asperger syndrome and pervasive developmental disorder not
otherwise specified form a spectrum of conditions (autism spectrum disorders or ASD) that is�…
otherwise specified form a spectrum of conditions (autism spectrum disorders or ASD) that is�…
Prenatal exposure to autism-specific maternal autoantibodies alters proliferation of cortical neural precursor cells, enlarges brain, and increases neuronal size in adult�…
V Mart�nez-Cerde�o, J Camacho, E Fox, E Miller…�- Cerebral�…, 2016 - academic.oup.com
Autism spectrum disorders (ASDs) affect up to 1 in 68 children. Autism-specific
autoantibodies directed against fetal brain proteins have been found exclusively in a�…
autoantibodies directed against fetal brain proteins have been found exclusively in a�…
Autism-specific maternal autoantibodies produce behavioral abnormalities in an endogenous antigen-driven mouse model of autism
KL Jones, MC Pride, E Edmiston, M Yang…�- Molecular�…, 2020 - nature.com
Immune dysregulation has been noted consistently in individuals with autism spectrum
disorder (ASD) and their families, including the presence of autoantibodies reactive to fetal�…
disorder (ASD) and their families, including the presence of autoantibodies reactive to fetal�…
Immunological and autoimmune considerations of Autism Spectrum Disorders
Abstract Autism Spectrum Disorders (ASD) are a group of heterogeneous
neurodevelopmental conditions presenting in early childhood with a prevalence ranging�…
neurodevelopmental conditions presenting in early childhood with a prevalence ranging�…
Brain-reactive IgG correlates with autoimmunity in mothers of a child with an autism spectrum disorder
L Brimberg, A Sadiq, PK Gregersen, B Diamond�- Molecular psychiatry, 2013 - nature.com
It is believed that in utero environmental factors contribute to autism spectrum disorder
(ASD). The goal of this study was to demonstrate, using the largest cohort reported so far�…
(ASD). The goal of this study was to demonstrate, using the largest cohort reported so far�…