Metabotropic glutamate receptor activation regulates fragile x mental retardation protein and FMR1 mRNA localization differentially in dendrites and at synapses

LN Antar, R Afroz, JB Dictenberg…�- Journal of�…, 2004 - Soc Neuroscience
Fragile X syndrome is caused by the absence of the mRNA-binding protein Fragile X mental
retardation protein (FMRP), which may play a role in activity-regulated localization and�…

Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile�…

RS Muddashetty, S Kelić, C Gross, M Xu…�- Journal of�…, 2007 - Soc Neuroscience
Fragile X syndrome, a common form of inherited mental retardation, is caused by the loss of
fragile X mental retardation protein (FMRP), an mRNA binding protein that is hypothesized�…

Metabotropic receptor-dependent long-term depression persists in the absence of protein synthesis in the mouse model of fragile X syndrome

ED Nosyreva, KM Huber�- Journal of neurophysiology, 2006 - journals.physiology.org
Fragile X syndrome (FXS), a form of human mental retardation, is caused by loss of function
mutations in the fragile X mental retardation gene (FMR1). The protein product of FMR1�…

[HTML][HTML] Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function

GJ Bassell, ST Warren�- Neuron, 2008 - cell.com
Fragile X syndrome is the most common inherited form of cognitive deficiency in humans
and perhaps the best-understood single cause of autism. A trinucleotide repeat expansion�…

Altered mRNA transport, docking, and protein translation in neurons lacking fragile X mental retardation protein

DI Kao, GM Aldridge, IJ Weiler…�- Proceedings of the�…, 2010 - National Acad Sciences
Fragile X syndrome is caused by the absence of functional fragile X mental retardation
protein (FMRP), an RNA binding protein. The molecular mechanism of aberrant protein�…

Fragile X mental retardation protein induces synapse loss through acute postsynaptic translational regulation

BE Pfeiffer, KM Huber�- Journal of neuroscience, 2007 - Soc Neuroscience
Fragile X syndrome, as well as other forms of mental retardation and autism, is associated
with altered dendritic spine number and structure. Fragile X syndrome is caused by loss-of�…

Localization of FMRP‐associated mRNA granules and requirement of microtubules for activity‐dependent trafficking in hippocampal neurons

LN Antar, JB Dictenberg, M Plociniak…�- Genes, Brain and�…, 2005 - Wiley Online Library
Fragile X syndrome is caused by the absence of the fragile X mental‐retardation protein
(FMRP), an mRNA‐binding protein, which may play important roles in the regulation of�…

[HTML][HTML] The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses

F Zalfa, M Giorgi, B Primerano, A Moro, A Di Penta…�- Cell, 2003 - cell.com
The Fragile X syndrome, which results from the absence of functional FMRP protein, is the
most common heritable form of mental retardation. Here, we show that FMRP acts as a�…

Metabotropic glutamate receptors and fragile x mental retardation protein: partners in translational regulation at the synapse

JA Ronesi, KM Huber�- Science signaling, 2008 - science.org
Fragile X syndrome (FXS) mental retardation is caused by loss-of-function mutations in an
RNA-binding protein, fragile X mental retardation protein (FMRP). Previous studies in�…

Fragile X mental retardation protein is necessary for neurotransmitter-activated protein translation at synapses

IJ Weiler, CC Spangler, AY Klintsova…�- Proceedings of the�…, 2004 - National Acad Sciences
Fragile X mental retardation is caused by absence of the RNA-binding protein fragile X
mental retardation protein (FMRP), encoded by the FMR1 gene. There is increasing�…