Observations of disease-associated changes in the basal ganglia are key to our current
understanding of cortico-thalamo-basal ganglia circuits. Postmortem findings of imbalances�…

The striatum is composed principally of GABAergic, medium spiny striatal projection neurons
(MSNs) that can be categorized based on their gene expression, electrophysiological�…

The striatum is a heterogeneous structure with a diverse range of neuron types and
neuromodulators. Three decades of anatomical and biochemical studies have established�…

Striosomes form neurochemically specialized compartments of the striatum embedded in a
large matrix made up of modules called matrisomes. Striosome-matrix architecture is�…

The striatum plays a central role in guiding numerous complex behaviors, ranging from
motor control to action selection and reward learning. The diverse responsibilities of the�…

The dopamine systems of the brain powerfully influence movement and motivation. We
demonstrate that striatonigral fibers originating in striosomes form highly unusual bouquet�…

The striatum is critically involved in execution of appropriate behaviors, but its internal
structures remain unmapped due to its unique structural organization, leading to ambiguity�…

One long-standing model of striatal function divides the striatum into compartments called
striosome and matrix. While some anatomical evidence suggests that these populations�…

The basal ganglia are an intricately connected assembly of subcortical nuclei, forming the
core of an adaptive network connecting cortical and thalamic circuits. For nearly three�…

The neostriatum has a mosaic organization consisting of striosome and matrix
compartments. It receives glutamatergic excitatory afferents from the cerebral cortex and�…