Recent studies provide new insight into the mechanistic function of Fragile X Mental
Retardation Protein (FMRP), paving the way to understanding the biological basis of Fragile�…

Fragile X syndrome, as well as other forms of mental retardation and autism, is associated
with altered dendritic spine number and structure. Fragile X syndrome is caused by loss-of�…

Fragile X syndrome is the most common inherited form of cognitive deficiency in humans
and perhaps the best-understood single cause of autism. A trinucleotide repeat expansion�…

Fragile X syndrome (FXS) mental retardation is caused by loss-of-function mutations in an
RNA-binding protein, fragile X mental retardation protein (FMRP). Previous studies in�…

Fragile X mental retardation protein (FMRP) is the product of the fragile X mental retardation
1 gene (FMR1), a gene that—when epigenetically inactivated by a triplet nucleotide repeat�…

Fragile X syndrome is the most common form of heritable mental retardation caused by the
loss of function of the fragile X mental retardation protein FMRP. FMRP is a multidomain�…

Abstract Fragile X Syndrome (FXS) is the most common form of inherited intellectual
disability and results from a loss of Fragile X mental retardation protein (FMRP). FMRP is�…

Abstract The Fragile X Mental Retardation Protein (FMRP) is an RNA-binding protein
essential to the regulation of local translation at synapses. In the mammalian brain�…

▪ Abstract Fragile X syndrome is one of the most common forms of inherited mental
retardation. In most cases the disease is caused by the methylation-induced transcriptional�…

mRNA localization and regulated translation play central roles in neurite outgrowth and
synaptic plasticity. A key molecule in these processes is the Fragile X mental retardation�…