The sorting of RNA molecules to subcellular locations facilitates the activity of spatially
restricted processes. We have analyzed subcellular transcriptomes of FMRP-null mouse�…

The Fragile X mental retardation-1 (Fmr1) gene encodes a multifunctional protein, FMRP,
with intrinsic RNA binding activity. We have developed an approach, antibody-positioned�…

FMRP, the fragile X mental retardation protein, is an RNA-binding protein that interacts
with∼ 4% of fetal brain mRNA. We have recently shown that a methyltransferase (MT) co�…

The molecular mechanisms that govern the maturation of oligodendrocyte lineage cells
remain unclear. Emerging studies have shown that N 6-methyladenosine (m 6 A), the most�…

Group I metabotropic glutamate receptors (mGluR) induce long-term depression (LTD) that
requires protein synthesis. Here, we demonstrate that Arc/Arg3. 1 is translationally induced�…

Fragile X syndrome is the most common form of inherited mental retardation, associated with
both cognitive and behavioral anomalies. The disease is caused by silencing of the fragile X�…

Summary N 6-methyladenosine (m 6 A) is the most abundant mRNA nucleotide modification
and regulates critical aspects of cellular physiology and differentiation. m 6 A is thought to�…

Genetic deficiency of the mRNA binding protein FMRP results in the most common inherited
form of mental retardation, Fragile X syndrome. We investigated the localization and function�…

The fragile X mental retardation protein FMRP is an RNA binding protein that associates
with a large collection of mRNAs. Since FMRP was previously shown to be a�…

Strong evidence indicates that regulated mRNA translation in neuronal dendrites underlies
synaptic plasticity and brain development. The fragile X mental retardation protein (FMRP) is�…