Fragile X syndrome is a common form of cognitive deficit caused by the functional absence
of fragile X mental retardation protein (FMRP), a dendritic RNA-binding protein that�…

The expression of the RNA-binding factor Fragile X mental retardation protein (FMRP) is
disrupted in the most common inherited form of cognitive deficiency in humans. FMRP�…

Summary N 6-methyladenosine (m 6 A), installed by the Mettl3/Mettl14 methyltransferase
complex, is the most prevalent internal mRNA modification. Whether m 6 A regulates�…

The fragile X syndrome (FXS), the most common form of inherited intellectual disability, is
due to the absence of FMRP, a protein regulating RNA metabolism. Recently, an�…

Silencing of FMR1 and loss of its gene product, FMRP, results in fragile X syndrome (FXS).
FMRP binds brain mRNAs and inhibits polypeptide elongation. Using ribosome profiling of�…

Fragile X syndrome is caused by the absence of functional fragile X mental retardation
protein (FMRP), an RNA binding protein. The molecular mechanism of aberrant protein�…

Loss of the RNA-binding fragile X protein [fragile X mental retardation protein (FMRP)]
results in a spectrum of cognitive deficits, the fragile X syndrome (FXS), while aging�…

ABSTRACT RNA epigenetics has received a great deal of attention in recent years, and the
reversible N6-methyladenosine (m6A) modification on messenger RNAs (mRNAs) has�…

Fragile X messenger ribonucleoprotein 1 protein (FMRP) binds many mRNA targets in the
brain. The contribution of these targets to fragile X syndrome (FXS) and related autism�…

RECENT studies have revealed that FMRP, the gene product of the fragile-X gene FMR1, is
an RNA-binding protein. These and other data have led to the idea that FMRP may play a�…