Loss of FMR1 gene function results in fragile X syndrome, the most common heritable form
of intellectual disability. The protein encoded by this locus (FMRP) is an RNA-binding�…

Abstract N 6-methyladenosine RNA (m6A) is a prevalent messenger RNA modification in
vertebrates. Although its functions in the regulation of post-transcriptional gene expression�…

Abstract N 6-Methyladenosine (m6A) is a dynamic mRNA modification which regulates
protein expression in various posttranscriptional levels. Functional studies of m6A in�…

RNA-binding proteins (RBPs) control messenger RNA fate in neurons. Here, we report a
mechanism that the stimuli-induced neuronal translation is mediated by phosphorylation of a�…

N6-methyladenosine (m6A) is the most abundant epitranscriptomic mark found on mRNA
and has important roles in various physiological processes. Despite the relatively high m6A�…

Background: Fragile X syndrome is caused by loss-of-function mutations in the fragile X
mental retardation 1 (FMR1) gene. How FMR1 affects the function of the central and�…

Abstract Background N 6-methyladenosine (m 6 A) modification in mRNAs was recently
shown to be dynamically regulated, indicating a pivotal role in multiple developmental�…

Fragile X syndrome is the most common form of inherited mental retardation caused by loss
of the fragile X mental retardation protein 1 (FMRP). The detailed molecular pathways�…

Fragile X Syndrome (FraX) is a broad-spectrum neurological disorder with symptoms
ranging from hyperexcitability to mental retardation and autism. Loss of the fragile X mental�…

The conserved modification N 6-methyladenosine (m6A) modulates mRNA processing and
activity. Here, we establish the Drosophila system to study the m6A pathway. We first apply�…