SHANK3 (also known as ProSAP2) regulates the structural organization of dendritic spines
and is a binding partner of neuroligins; genes encoding neuroligins are mutated in autism�…

Autism spectrum disorders comprise a range of neurodevelopmental disorders
characterized by deficits in social interaction and communication, and by repetitive�…

Mutations in the postsynaptic scaffolding gene SHANK2 have recently been identified in
individuals with autism spectrum disorder (ASD) and intellectual disability. However, the�…

Using microarrays, we identified de novo copy number variations in the SHANK2 synaptic
scaffolding gene in two unrelated individuals with autism-spectrum disorder (ASD) and�…

Mutations in several postsynaptic proteins have recently been implicated in the molecular
pathogenesis of autism and autism spectrum disorders (ASDs), including Neuroligins�…

Genetic mutations of SHANK3 have been reported in patients with intellectual disability,
autism spectrum disorder (ASD) and schizophrenia. At the synapse, Shank3/ProSAP2 is a�…

Autism spectrum disorder (ASD) is a group of conditions characterized by impaired social
interaction and communication, and restricted and repetitive behaviours. ASD is a highly�…

Several large-scale genomic studies have supported an association between cases of
autism spectrum disorder and mutations in the genes SH3 and multiple ankyrin repeat�…

SHANK3 (also known as PROSAP2) is a postsynaptic scaffolding protein at excitatory
synapses in which mutations and deletions have been implicated in patients with idiopathic�…

Because autism spectrum disorders are neurodevelopmental disorders and patients
typically display symptoms before the age of three, one of the key questions in autism�…