Frontostriatal involvement in task switching depends on genetic differences in d2 receptor density
Recent studies suggest an association of dopamine D2 receptor (DRD2) availability with
flexibility in reward-based learning. We extend these results by demonstrating an�…
flexibility in reward-based learning. We extend these results by demonstrating an�…
Dopaminergic regulation of vestibulo-cerebellar circuits through unipolar brush cells
While multiple monoamines modulate cerebellar output, the mechanistic details of
dopaminergic signaling in the cerebellum remain poorly understood. We show that�…
dopaminergic signaling in the cerebellum remain poorly understood. We show that�…
[HTML][HTML] Pathway-specific remodeling of thalamostriatal synapses in parkinsonian mice
PRL Parker, AL Lalive, AC Kreitzer�- Neuron, 2016 - cell.com
Movement suppression in Parkinson's disease (PD) is thought to arise from increased
efficacy of the indirect pathway basal ganglia circuit, relative to the direct pathway. However�…
efficacy of the indirect pathway basal ganglia circuit, relative to the direct pathway. However�…
[HTML][HTML] Bidirectional optogenetic modulation of the subthalamic nucleus in a rodent model of Parkinson's disease
Parkinson's disease (PD) is a neurodegenerative disorder characterized by a range of motor
symptoms. Treatments are focused on dopamine replacement therapy or deep brain�…
symptoms. Treatments are focused on dopamine replacement therapy or deep brain�…
Disease-associated changes in the striosome and matrix compartments of the dorsal striatum
JR Crittenden, AM Graybiel�- Handbook of behavioral neuroscience, 2016 - Elsevier
Observations of disease-associated changes in the basal ganglia are key to our current
understanding of cortico-thalamo-basal ganglia circuits. Postmortem findings of imbalances�…
understanding of cortico-thalamo-basal ganglia circuits. Postmortem findings of imbalances�…
Nonlinear effects of dopamine D1 receptor activation on visuomotor coordination task performance
Dopamine plays an important role in the modulation of neuroplasticity, which serves as the
physiological basis of cognition. The physiological effects of dopamine depend on receptor�…
physiological basis of cognition. The physiological effects of dopamine depend on receptor�…
[HTML][HTML] Optogenetic astrocyte activation modulates response selectivity of visual cortex neurons in vivo
Astrocytes play important roles in synaptic transmission and plasticity. Despite in vitro
evidence, their causal contribution to cortical network activity and sensory information�…
evidence, their causal contribution to cortical network activity and sensory information�…
Genetic suppression of the dopamine D3 receptor in striatal D1 cells reduces the development of L-DOPA-induced dyskinesia
Parkinson's Disease (PD) is symptomatically managed with L-DOPA but chronic use results
in L-DOPA-induced dyskinesia (LID) characterized by abnormal involuntary movements�…
in L-DOPA-induced dyskinesia (LID) characterized by abnormal involuntary movements�…
Balancing the basal ganglia circuitry: a possible new role for dopamine D2 receptors in health and disease
Current therapies for treating movement disorders such as Parkinson's disease are effective
but limited by undesirable and intractable side effects. Developing more effective therapies�…
but limited by undesirable and intractable side effects. Developing more effective therapies�…
[HTML][HTML] Optogenetic glia manipulation: possibilities and future prospects
WH Cho, E Barcelon, SJ Lee�- Experimental neurobiology, 2016 - ncbi.nlm.nih.gov
Our brains are composed of two distinct cell types: neurons and glia. Emerging data from
recent investigations show that glial cells, especially astrocytes and microglia, are able to�…
recent investigations show that glial cells, especially astrocytes and microglia, are able to�…