The genetic and phenotypic heterogeneity of autism spectrum disorders (ASD) presents a
substantial challenge for diagnosis, classification, research, and treatment. Investigations�…

The genetic architecture of autism spectrum disorder (ASD) is itself a diverse allelic
spectrum that consists of rare de novo or inherited variants in hundreds of genes and�…

Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopmental
disorders of genetic and environmental etiologies. Some ASD cases are syndromic�…

Many candidate genes are now thought to confer susceptibility to autism spectrum disorders
(ASDs). Here we review four interrelated complexes, each composed of multiple families of�…

Autism spectrum disorder (ASD) encompasses a group of multifactorial neurodevelopmental
disorders characterized by impaired social communication, social interaction and repetitive�…

Genetics studies of autism spectrum disorder (ASD) have identified several risk genes that
are key regulators of synaptic plasticity. Indeed, many of the risk genes that have been�…

Identifying converging pathways in syndromic forms of ASD will uncover novel therapeutic
targets for non-syndromic ASD. Insights into developmental synaptopathies will lead to�…

The diagnosis of debilitating psychiatric disorders like autism spectrum disorder (ASD) and
schizophrenia (SCHZ) is on the rise. These are severe conditions that lead to social isolation�…

Characterized by a combination of abnormalities in language, social cognition and mental
flexibility, autism is not a single disorder but a neurodevelopmental syndrome commonly�…

Highlights•High throughput genomic methods are rapidly increasing the pool of ASD
genes.•Heterogeneity, pleiotropy, and brain complexity complicate translation to�…