The uptake, distribution and excretion of curcumin in Sprague‐Dawley rats has been
studied. When administered orally in a dose of 1 g/kg, curcumin was excreted in the faeces�…

When everted sacs of rat intestines were incubated with 50–750 μg of curcumin in 10 ml
incubation medium, 30–80% of the added curcumin disappeared from the mucosal side. No�…

After oral administration of 400 mg curcumin to rats, about 60% of the dose was absorbed.
No curcumin was detectable in urine. The urinary excretion of conjugated glucuronides and�…

The medicinal properties of curcumin obtained from Curcuma longa L. cannot be utilised
because of poor bioavailability due to its rapid metabolism in the liver and intestinal wall. In�…

1. Cureumin labelled with deuterium and tritium was prepared. Oral and intraperitoneal
doses of [3H] curcumin led to the faecal excretion of most of the radioactivity. 2. Intravenous�…

Studies in vitro and in animal models of colorectal and hepatocellular cancers suggest that
curcumin is an effective chemopreventive agent. In this pilot trial, we investigated whether�…

Radiocativity was detectable in blood, liver and kidney following dosage with 400, 80 or 10
mg of [3 H] curcumin. The major route of elimination of the label was the feces: the urinary�…

In rats fed cholesterol and curcumin, the coloring principle in turmeric, levels of serum and
liver cholesterol fell to one-half or one-third of those in rats fed cholesterol and no curcumin�…

Purpose Curcumin, a major constituent of the spice turmeric, suppresses expression of the
enzyme cyclooxygenase 2 (Cox-2) and has cancer chemopreventive properties in rodents. It�…

Scope Curcumin (CUR) and its major metabolite hexahydro‐CUR were studied in C aco‐2
cells and in the C aco‐2 M illicell� system in vitro to simulate their in vivo intestinal�…